超敏C反应蛋白测定在恶性肿瘤诊断中的意义

Significance of serum high sensitivity C-reactive protein in the diagnoses of malignant tumor

目的探讨超敏C反应蛋白(highsensitivityC-reactiveprotein,hs-CRP)在恶性肿瘤诊断中的临床应用价值。方法应用免疫速率散射比浊法测定治疗前的253例恶性肿瘤、99例良性肿瘤、92例炎性包块患者及200例健康人血清hs-CRP水平。结果恶性肿瘤组及炎性包块组的血清hs-CRP明显高于良性肿瘤组和正常对照组(P<0.01),且炎性包块组的血清hs-CRP水平高于恶性肿瘤组(P<0.01),而良性肿瘤组hs-CRP与正常对照组比较无统计学意义(P>0.05)。结论在排除感染、创伤等引起CRP升高的情况下,患者血清hs-CRP升高要考虑恶性肿瘤的可能,CRP在恶性肿瘤诊断及病情评估上具有一定的临床意义。

[Objective] To explore the significanc of serum hs-CRP in patients with malignant tumor. [Methods] Serum hs-CRP in 253 patients with malignant tumor, 99 patients with benign tumor, 92 patients with inflammatory mass and 200 healthy people were evaluated by turbidimetric method based on the peak rate principle. [Resuits] The level of serum hs-CRP in patients with inflammatory mass or malignant tumor were significantly higher than that in patients with benign tumor or normal control （P 〈0,01）, and hs-CRP in inflammatory mass group was higher than that in malignant tumor （P 〈0.01）. There was no difference between benign tumor group and normal control （P 〉0.05）. [Conclusion] The elevation of serum hs-CRP suggests the possibility of malignant tumor when inflammation, trauma and other disease which can cause the elevation of CRP, It＇s useful in the diagnosis and progression of malignant tumor.