期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

高敏C-反应蛋白对急性冠脉综合征患者预后的评价作用 被引量：3

下载PDF
导出
摘要 目的探讨高敏C-反应蛋白(hs-CRP)在急性冠脉综合征(ACS)患者血清中的变化及不同水平对ACS预后的预测价值。方法采用乳胶凝集反应法测定118例ACS患者和40例正常对照组血清hs-CRP浓度,随访1年,记录心血管事件的发生率。结果ACS各组hs-CRP值均明显高于正常对照组(P<0.01),而心梗组hs-CRP值又高于不稳定心绞痛组(P<0.01)。110例ACS患者中发生心血管事件27例,RR值为2.32,95%CI为0.95￣5.64,P=0.0438,且随着hs-CRP值逐渐升高,发生心血管事件的危险性也逐渐增加。结论炎症反应在ACS的发病机制中起重要作用,并可作为ACS患者预后的预测指标。
作者 俞燕 吴翔 魏美芳 于小红
机构地区 南通大学附属医院心内科
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2006年第16期2544-2546,共3页 China Journal of Modern Medicine
基金 南通市科委社会发展科技计划项目(No:30013)
关键词 高敏C-反应蛋白 急性冠脉综合征 预后
分类号 R541.1 [医药卫生—心血管疾病]
  • 相关文献

参考文献11

  • 1BRAURRWALD E,ANTAMAN EM,BEASLEY JW,et al.ACC/AHA guidelines for the management of patient with unstable angina and non ST segment elevation myocardial infarction:a report of the American college of cardiology/American heart association task force on practice guidelines (commmitte on the management of patient with unstable angina)[J].Circulation,2000,102(10):1193-1209.
  • 2李旭平,张志辉,周胜华,刘启明,方臻飞,祁述善.妊娠相关蛋白酶-A、C-反应蛋白、丙二醛化低密度脂蛋白的变化与急性冠脉综合征相关性研究[J].中国现代医学杂志,2005,15(1):86-88. 被引量：2
  • 3NADER RIFAI,PAUL MR IDKER.High-sensitivity C-reactive protein:a novel and promising marker of coronary heart disease[J].Clin Chem,2001,47:403.
  • 4BRAURRWALD E,ANTAMAN EM,BEASLEY JW,et al.ACC/AHA guidelines for the management of patient with unstable angina and non ST segment elevation myocardial infarction:a repoet of the americal college of cardiology/American heart association task force on practice guidelines (committee on the management of patient with unstable angina)[J].J Am Coll Cardiol,2000,36(3):970.
  • 5HAVERKATE F,SIMON G THOMPSON,STEPHEN DM PY KE,et al.Production of C-reactive protein and risk of coronary events in stable and unstable angina[J].Lancet,1997,9050(349):462-466.
  • 6EH ET,WILLERSON JT.Coming of age of C-reactive protein:using inflammation markers in cardiology[J].Circulation,2003,107:370-371.
  • 7CULLEN P,VON ECKARDSTEIN A,ASSMANN G.Diagnosis and management of new cardiovascular risk factors[J].Eur Heart J,1998,19:13.
  • 8ROSS R.Atherosclerosis-is an inflammatory disease[J].N Engl J Med,1999,340:115.
  • 9TOSS H,LINDADHL B,SEIBAHN A,et al.Prognostic influence of increased fibrinogen and C-reactive protein levels in unstable coronary artery disease[J].Circulation,1997,96:4204-4210.
  • 10RIDKER PM,CUSHMAN M,STAMPFER MJ,et al.Inflammation,aspirin,and the risk of cardiovascular disease in apparently healthy men[J].N Engl J Med,1997,36:973-979.

二级参考文献11

  • 1HAVERKATE F, THOMPSON SG, PYKE SDM, et al. For the European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group Production of C-reactive protein and risk of coronary events in stable and unstable angina[J]. Lancet,1997, 349: 462-466.
  • 2MALLAT Z, CORBAR A, SCOAZEC A, et al. Expression of Interleukin-18 in human athemsderotic plaques and relation to plaque instability[J]. Circulation, 2001, 104: 1598-1603.
  • 3ROSS R. Atherosclerosis-An inflammatory disease [J]. N Engl Med, 1999, 340: 115-126.
  • 4ARAKI T, KANAYA H,KANAYA H, et al. Charges in serum low lipoprotein in patients with acute myocardial infarction and stable angina pectoris treated by coronary angioplasty[J]. J Cariaol, 2001, 38: 55-60.
  • 5KRISTENSON T, OXVIG C, SCAND O, et al. Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned eDNA[J]. Biochemistry, 1994, 33: 1592-1598.
  • 6BAYES-GENIS A, CONOVER CA, OVERGAARD MT, et al.Pregnancy-associated plasma protein-a as a marker of acute coronary syndromes[J]. N Engl Med, 2001, 345: 1022-1029.
  • 7CASKA IL STULE T, ZIMA T, et al. PARR-A a novel marker of unstable plaque is not influenced by hypolipidemic treatment in contrast CRP[J]. Athevosclerosis, 2003, 166: 195-196.
  • 8ABDELLMOUTrALEB I, DANCHIN W, ILARDO C. Evidence of the implication of an inflammatory process in acute coronary syndromes[J]. Am Heart J, 1999, 137: 346-351.
  • 9PdDKER PM, CUSHMAN M, STAMPFER MJ, et al. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men[J]. N Engl Meal, 1997, 336; 973-979.
  • 10HOLVOET P, VANHAECKE J, JANSSENS S, et al. Oxidized LDL and malondialdehyde-modified LDL in patients with ACS and stable coronary artery disease[J]. Circulation, 1998, 98:1487-1494.

共引文献1

同被引文献41

引证文献3

二级引证文献12

中国现代医学杂志
2006年 第16期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部