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调节性T细胞在哮喘治疗中的新进展 被引量：2

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摘要 支气管哮喘的免疫机制Th1/Th2平衡紊乱受多种因素的调节。该文主要描述了CD4+调节T细胞的两个主要亚群自然调节性T细胞和获得性调节性T细胞,它们分别在抑制自身免疫反应和获得性免疫反应起重要作用。获得性CD4+调节T细胞又可根据分泌不同的细胞因子IL-10和TGF-β,分为Tr1型细胞和Th3型细胞。了解调节性T细胞的免疫调节机制有助于开拓哮喘治疗的新方法。
作者 何皓頔 陈吉泉 修清玉
机构地区 第二军医大学长征医院呼吸内科
出处 《国际呼吸杂志》 2006年第8期592-594,共3页 International Journal of Respiration
基金 国家自然科学基金资助项目(30200116)
关键词 调节性T细胞 哮喘 治疗
分类号 R562.25 [医药卫生—呼吸系统]
  • 相关文献

参考文献23

  • 1Herrick CA,Bottomly K.To respond or not to respond:T cells in allergic asthma.Nat Rev Immunol,2003,3(5):405-412.
  • 2Gor DO,Rose NR,Greenspan NS.Th1-Th2:a Procrustean paradigm.Nat Immunol,2003,4(6):503-505.
  • 3Kitani A,Fuss I,Nakamura K,et al.Transforming growth factor (TGF)-b1-producing regulatory T cells induce smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-b1-mediated fibrosis.J Exp Med,2003,198(8):1179-1188.
  • 4Walker MR,Kasprowicz DJ,Gersuk VH,et al.Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells.J Clin Invest,2003,112(9):1437-1443.
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  • 8王艳 ,胡劲松 ,王一理 ,司履生 .调节性T细胞的研究进展[J].国外医学（免疫学分册）,2005,28(4):243-246. 被引量：2
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  • 10Kitani A,Fuss I,Nakamura K,et al.Transforming growth factor (TGF)-b1-producing regulatory T cells induce smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-b1-mediated fibrosis.J Exp Med,198(8):1179-1188.

二级参考文献34

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共引文献6

同被引文献11

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二级引证文献19

国际呼吸杂志
2006年 第8期

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