地尔硫和硝酸甘油对高血压急症的疗效比较

An Efficacy Comparison Study of Intravenous Diltiazem versus Nitroglycerol in Treating Acute Hypertension

目的研究地尔硫和硝酸甘油静脉应用治疗高血压急症的效果比较。方法90例确诊为高血压急症的患者,随机分成地尔硫组50例,硝酸甘油组40例,分别采用静脉点滴的方法,连续检测心率血压的变化,记录降压前后心率(H R)、收缩压(SBP)、舒张压(DBP),计算心率收缩压乘积(RPP),并记录血压降至正常范围时所需时间(T),比较两组治疗效果。结果地尔硫组有效率达100%,明显高于硝酸甘油组(有效率80%),P<0.05。效果显著,且心肌耗氧量降低,副作用较硝酸甘油明显减少。结论静脉应用地尔硫治疗高血压急症效果较硝酸甘油显著、可靠。

Objective To evaluate the efficacy of intravenous diltiazem versus nitroglycerol in treating acute hypertension. Methods A random study including 90 patients with acute hypertension was conducted to evaluate the efficacy of intravenous diltiazem versus nitroglycerol, of which 50 patients were treated with diltiazem and 40 patients were treated with nitroglycerin in intravenous drip, respectively. The curative effects of two groups were compared by monitoring the changes in heart rate and blood pressure, recording heart rate （ HR ）, systolic blood pressure （ SBP ） and diastolic blood pressure （ DBP ） before and after administration, calculating rate-pressure product （ RPP ） and the time （T） needed for blood pressure decreasing to the normal range. Results Compared with the patients treated with nitroglycerin （80%）, the total effective rate was better for patients treated with diltiazem （100%）, P〈0.05. Moreover, the myocardial oxygen consumption and side effect of patients treated with diltiazem were both lower than that of patients treated with nitroglycerin. Conclusion The efficacy of intravenous diltiazem in treating acute hypertension is better and safer than that of intravenous nitroglycerin.