参麦与依美思治疗新生儿缺氧缺血性脑病疗效观察

Shenmai And Yimeisi Treating Hypoxie-ischemicEncephalopathy's Cative Effect Observation

目的比较单用参麦与联合应用依美思治疗新生儿缺氧缺血性脑病的疗效。方法选择2001～2004年在我院新生儿室住院的新生儿缺氧缺血性脑病患儿共182例,随机分为治疗组甲、乙组和对照组丙组;其中对照组57例,以支持对症治疗为主,治疗组甲组60例,在对照组基础上加用参麦治疗,治疗组乙组65例,为同时加用参麦及依美思治疗,观察三组的治疗效果,以临床主要症状、体征消失时间作为判断指标,同时进行新生儿行为神经评分。结果治疗组(甲、乙)总有效率分别为83.3%,93.8%,对照组(丙)63.1%;治疗组在临床症状、体征消失时间较对照组明显缩短;20项行为神经评分,治疗组亦明显高于对照组,经统计学分析,两组对比差异有显著性,P<0.05。结论参麦、依美思治疗新生儿缺氧缺血性脑病近期疗效显著,并且具有协调作用。

Objectiive Compare the curative effect that one is to use shenmai only and the other is to join in yimeisi to treat hypoxie-ischemic encephalopathy . Methods to choose 182 newborn baby which suffered from hypoxie-ischemic encephalopathy lived in the newborn room in our hospital from 2001 to 2004. Randomly separate into tream teams A and B, and comparative team C. Comparative team have 57 examples in it, mainly using support and symtom treatment. Treat team A have 60 examples, add to shenmai on the basis of the comparative team. Treat team B have 65 examples, add to shenmai and yimeisi in the same time. To observe the three teams＇ curative effect, put the main clinical symtom and objective sign disappearing for judyment indicator, and make the newborn baby nervous mark in the same time. Results The treat teams＇ （A and B） overall effective rate are separately 83.3% and 93.8%,the comparative team（C） is 63.1%.On the time of clinical symtom and objective sign disappearing, the treat teams are sensible short than the comparative team. On 20 hebavior nervous mark, the treat teams are also sensible higher than the comparative team. Through statistics analysis, there is obvious comparative difference in the two teams, p〈0. 05. Conclusion There is recent obvious curative effect that join in shenmai and yimeisi to treat hypoxie-ischemic encephalopathy ,and there is also synergistic effect.