幽门螺杆菌感染的分子机制

Molecular Mechanism of Helicobacter pylori Infection

幽门螺杆菌(Helicobacterpylori)是居留于人胃上皮组织并引起胃炎、消化性胃溃疡和胃癌的病原菌。近年来,随着幽门螺杆菌全基因组序列的报道和功能基因的研究深入,对幽门螺杆菌的感染的分子、免疫等机制逐渐阐明。现对幽门螺杆菌基因组特点和幽门螺杆菌黏附、毒性因子等对人体感染的分子机制等方面的研究进展做一综述。

Helicobacterpylori colonizes the human gastric epithelium and is responsible for gastritis, peptic ulcer, and gastric cancer. In recent years, with publish of the complete genome sequence of H. pylori and deep research of functional genes of this organism, the molecular mechanism of H. pylori infection and the immune response are more in depth understanding. In the paper, We summarize the characteristic of H. pylori genome and molecular mechanism which H. pylori infect human by adhere to the gastric cells and a unique set of virulence factors.