期刊文献+

弯曲血管中的血液流动和大分子传质

Blood Flow and Macromolecular Transport in Curved Blood Vessels
下载PDF
导出
摘要 采用数值模拟的方法,研究主动脉弯曲血管中的定常/脉动流动及低密度脂肪蛋白(LDL)和血清白蛋白(Albumin)传质.计算结果表明,对于主动脉弓模型,二次流漩涡的位置随时间变化.在弯曲变化比较剧烈的区域大分子浓度较高,壁面浓度外壁高于内壁.这些流动变化比较剧烈的区域可能是动脉硬化或血栓形成的危险区域. A numerical analysis of the steady/pulsatile flow and macromolecular (such as LDL and Albumin) transport in curved blood vessels was carried out. The computational results predict that the vortex of the secondary flow is time-dependent in the aortic arch. The concentration of macromolecule concentrates at the region of sharp curve, and the wall concentration at the outer part is higher than that at the inner part. Atherosclerosis is prone to develop in such regions with sharp flow.
出处 《应用数学和力学》 CSCD 北大核心 2006年第9期1071-1078,共8页 Applied Mathematics and Mechanics
基金 国家自然科学基金资助项目(10372007 30571900 10572006) 北京市自然科学基金资助项目(7062015)
关键词 弯曲血管 血液流动 大分子传质 动脉粥样硬化 curved blood vessels blood flow macromolecular transport atherosclerosis
  • 相关文献

参考文献17

  • 1温功碧.动脉粥样硬化成因和大分子跨血管的传质[J].力学进展,1993,23(2):223-233. 被引量:5
  • 2Dean W R.Note on the motion of fluid in a curved pipe[J].Phil Magazine,1927,4(20):208-223.
  • 3Shahcheraghi N,Dwyer H A,Cheer A Y,et al.Unsteady and three-dimensional simulation of blood flow in the human aortic arch[J].J Biomechanical Engineering,2002,124 (4):378-387.
  • 4Chang L J,Tarbell J M.Numerical simulation of fully developed sinusoidal and pulsatile (physiological) flow in curved tubes[J].J Fluid Mech,1985,161:175-198.
  • 5Tomai Yutaka,Tanishita Kazuo.Fully developed intermittent flow in a curved tube[J].J Fluid Mech,1997,347:263-287.
  • 6Torii Ryo,Oshima Marie.Numerical simulation system for blood flow in the cerebral artery using CT imaging data[J].JSME Internat J,Ser C,2001,44(4):982-989.
  • 7Moore James E,Weydahl Erlend S,Santamarina Aland.Frequency dependence of dynamic curvature effects on flow through coronary arteries[J].J Biomechanical Engineering,2001,123(2):129-133.
  • 8QIU Yu-chen,Tarbell John M.Numerical simulation of pulsatile flow in a compliant curved tube model of coronary artery[J].J Biomechanical Engineering,2000,122(1):77-85.
  • 9乔爱科,刘有军,伍时桂.弯曲动脉的血流动力学数值分析[J].计算力学学报,2003,20(2):155-163. 被引量:32
  • 10Rappitsch G,Perktold K.Pulsatile albumin transport in large arteries:a numerical simulation study[J].J Biomechanical Engineering,1996,118(4):511-519.

二级参考文献53

  • 1温功碧.动脉粥样硬化成因和大分子跨血管的传质[J].力学进展,1993,23(2):223-233. 被引量:5
  • 2沈崇棠 刘鹤年.非牛顿流体力学及其应用[M].北京:高等教育出版社,1989.159-162.
  • 3伍时桂 李兆治 等.非线性波在动脉内传播的数值研究[J].北京工业大学学报,1988,14(2):44-52.
  • 4吴望一.流体力学(上册)[M].北京:北京大学出版社,1995.1-239.
  • 5李娟.弯曲血管中流动的结构稳定性的理论分析和数值计算:学位论文[M].北京:北京大学力学和工程科学系,1988,6..
  • 6祈孝康 刘儒勋 等.计算流体力学[M].北京:国防科技大学出版社,1989.220-251.
  • 7温功碧.三维定常/非定常不可压缩流动N-S方程基于人工压缩性方法的数值模拟[R]..中国空气动力研究和发展中心技术报告[C].,2001..
  • 8[1]Back L H, Liem T K, Kwack E Y. et al. Flow measurements in a highly curved atherosclerotic coronary artery cast on man[J]. J Biomechanical Engineering,1992,114(2):232-240.
  • 9[2]Perktold K, Resch M. Numerical flow studies in human carotid artery bifurcations: basic discussion of the geometric factor in atherogenesis[J]. J Biomedical Eng,1990,12(1):111-123.
  • 10[3]Fry D L. Certain histological and chemical responses of the vascular interface of acutely induced mechanical stress in the aorta of the dog[J]. Circulation Research,1969,24(1):93-109.

共引文献57

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部