颈动脉粥样硬化危险因素分析

An analysis of risk factors of carotid atherosclerosis

目的:探讨颈动脉粥样硬化(CAS)的危险因素及与相关炎症因子产生的关系。方法:入选的83例对象均行彩色多普勒检测颈动脉内中膜厚度(IMT)及观察颈动脉有无斑块,根据结果分成A组即CAS组(颈动脉IMT≥1.0mm和/或颈动脉斑块)及B组(颈动脉IMT<1.0mm及无颈动脉斑块),分析两组各危险因素和炎症因子产生之间的差异。结果:A组中血脂代谢紊乱、收缩压(SBP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C),血尿酸(UA),脂蛋白a(Lp(a)),超敏C反应蛋白(Hs-CRP),白介素6(IL-6)及纤维蛋白原(FIB)较B组差异明显(P<0.05)。Logistic多元回归分析发现,男性、LDL-C、IL-6是CAS的独立危险因素。结论:在CAS的发生发展中除了传统的危险因素外,炎症因子也起了非常重要的作用。

Objective： To analyze the risk factors of carotid atherosclerosis （CAS）. Methods： Totally 83 patients were examined by B-mode ultrasound to measure intima-media thickness（IMT） of the common carotid artery and plaque formation. The patients were divided into group A （carotid IMT 1〉 1.0 mm and/or the presence of carotid plaque） and group B（carotid IMT 〈 1.0 mm and the absence of carotid plaque）. The differences of the nsk factors between two groups were analyzed. Results： The levels of systolic blood pressure （SBP）, total cholesterol （TC）, low dense lipoprotein cholesterol （LDL-C）, uric acid （UA）, lipoprotein a [ Lp （a） ], high sensitive C-reactive protein （Hs-CRP）,Interleukin-6 （IL-6） and fibrinogen （FIB） in group A were significantly higher than those in group B （P 〈 0.05）. The result of logistic regression analysis indicated that male,LDL-C and IL-6 were the independent risk factors. Conclusion： The traditional risk factors and the inflammatory markers are strongly and closely related to the occurrence and development of CAS.