祛风清热化瘀通络汤治疗类风湿关节炎60例疗效观察

Observation of Qufengqingro Huayutongluo Decoction on the treatment of rheumatoid arthritis

目的观察祛风清热化瘀通络汤治疗类风湿关节炎(RA)的临床疗效。方法120例类风湿关节炎患者随机分为2组,治疗组60例应用祛风清热化瘀通络汤,随症加减,水煎服,每日1剂。对照组60例应用芬必得胶囊,每次0.3 g,每日2次口服;雷公藤多甙片,每次2片,每日3次口服。观察2组疗效、症状和体征及实验室检查指标。结果治疗组总有效率91.67%,对照组总有效率86.67%,2组比较无显著性差异(P>0.05);治疗组治疗后关节疼痛、肿胀、压痛、晨僵均有改善(P<0.05),而对照组只能改善关节疼痛、肿胀和压痛(P<0.05),而不能改善晨僵(P>0.05);2组治疗后红细胞沉降率(ESR)、类风湿因子(RF)、C-反应蛋白(CRP)、免疫球蛋白(Ig)与治疗前比较均降低(P<0.05),且降低ESR、CRP、IgG方面优于对照组(P<0.05);毒性和不良反应明显少于对照组。结论祛风清热化瘀通络汤治疗RA疗效确切。

Methods 120 Patients with rheumatoid arthritis were randomly divided into two groups. Patients in control groups （ n =60） were treated by routine therapy （buprofen, 300mg, twice a day, Glueosidorum Tripterygll Totorum, 2 tablets, three times a day）. Patients in treatment groups （ n = 60） were treated by Qufengqingro Huayutongluo Decoction. Changes of sings, symptoms and Lab index were observed in both groups. Result The total effective rate in treatment group （91.67%） was not higher than that in control group （86.67%, P〉0.05）. There was improvement of arthralgia, engorgemen, tenderness, and morning stiffness after treatment in treatment group （ P〈0.05）. There was not improvement of morning stiffness after treatment in control group （ P〉0.05）. But there were improvements of arthralgia, engorgemen, and tenderness after treatment in control group （ P〈0.05）. ESR, RF, CRP and IgG after treatment were decreased than those before treatment in both groups （ P〈0.05）. The results showed that decrease of ESR, RF, CRP in treatment group were superior Io those in control group （ P〈0.05）. Conclusion Qufengqingro Huayutongluo Decoction has a good effect on treating rheumatoid arthritis.