家族性支气管哮喘的遗传方式分析

Analysis of the Mode of Inheritance in Familial Bronchial Asthma

为研究家族性支气管哮喘的遗传方式,进一步确定在群体中的传递规律,用群体研究法调查邯郸地区有家族史的支气管哮喘家系。采用家系分析法和Smith无偏差校正法,进行理论值与观察值符合程度的卡方检验分析。72个家族性支气管哮喘的家系,包括109个核心家系,其亲属的患病率为0.46。分析结果表明,有单基因遗传的倾向。用家系法分析,符合常染色体显性遗传。对D-×dd婚配家系用Smith法分析,χ2=3.181,P>0.05,所得结果支持常染色体显性遗传(Autosomaldomiantinheritance,AD),并提示不同的婚配类型,遗传方式可能不同,存在着遗传异质性,研究结果可为家族性支气管哮喘的预防、诊断和治疗提供参考依据。

To study the mode of inheritance of familial bronchial asthma and to understand the population genetics laws of bronchial asthma, Families with a family history of bronchial asthma in Handan region were investigated using group research method. The χ^2 test of the degree of coincidence between the expected and observed values was analyzed by pedigree analysis and the ＂Smith＂ agonic revise method. The incidence rate within the 72 families pedigree with familial bronchial asthma, including 109 core pedigrees, is 0.46. Analysis shows a tendency towards single gene inheritance. Pedigree analysis reveals that it is consistent with autosome dominant inheritance. Analysis of the D- × dd marriage with the ＂Smith＂ analytical method supports this conclusion （χ2=3.181,P〉 0.05） and further hints there exists genetic heterogeneity, i.e. different modes of inheritance among different marriage types. Our results can offer the reference to the prevention, diagnosis and treatment of familial bronchial asthma.