摘要
在噬菌体phi29中,基因组DNA的包装需要由病毒基因组编码的pRNA参与,6个pRNA分子通过由pRNA分子间相互作用形成的六聚体来启动DNA转运马达,这个过程由ATP提供能量。RNA纳米技术将pRNA与siRNA、核酶、反义RNA等分子稳定结合,pRNA作为一种载体把它们准确运输到癌细胞和病毒感染细胞的作用靶点,从而发挥它们各自的功能。作为一种非编码RNA,对pRNA的深入研究将有助于我们了解生命起源问题,并有着广阔的应用前景。
In the bacteriophage phi29, a virus-encoded RNA（pRNA） is required for the packaging of its genomic DNA. Six pRNAs form a hexamer through pRNNpRNA interaction to drive the DNA translocation motor, and ATP as the energy resource. Chimeric pRNAs can steadily combine with siRNA, ribozymes and anti-sense RNA, and then be transferred into the cancer cells and viral-infected cells by RNA nanotechnology. The continued study of pRNA will help us to understand the origin of the life and explore its possible applications.
出处
《遗传》
CAS
CSCD
北大核心
2006年第9期1180-1184,共5页
Hereditas（Beijing)
