冠心病患者胰岛素抵抗与冠状动脉病变的相关性分析

The Relationship between Insulin Resistance and Coronary Artery Disease

目的:探讨胰岛素抵抗(IR)与冠状动脉病变的相关性。方法:采用病例对照研究方法,153例经冠脉造影确诊的冠心病患者为观察组,85例造影正常者为对照组,对冠状动脉病变程度进行分型,观察其与冠心病危险因素相关指标的关系。结果:冠心病患者胰岛素抵抗指数(IRI)、体重指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)明显增高,高密度脂蛋白(HDL)明显降低。IRI与冠脉病变类型呈明显相关(P<0．001)。结论:IRI与冠脉病变具有正相关关系,增加胰岛素敏感性对于防治心血管疾病具有重要意义。

Objective.. To investigate the relationship between insulin resistence and the severity of coronary heart disease （CHD）. Methods ..238 patients with CHD who undergone coronary angiography were included in this study. According to the angiography results,patients were divided into CHD group （n= 153） and control group （n=85）. The severity of coronary artery lesions and levels of plasma lipids,plasma glucose, insulin and body mass index（BMS） were measured. Results： Compared to the control group, IR,TC,TG,and LDL levels in CHD group increased significantly. There were correlationship between in sulin resistance index（IRI） and the classification of coronary artery lesions,P〈0. 001. Conclusion.. Higher IRI has positive relation with the severity of coronary artery lesions. Improving insulin sensitivity would decrease cardiovascular risk in high risk population.