脉压、脉压指数、血管硬化指数、脉搏传导速度临床应用比较研究

Oinical Comparison of Pulse Wave Velocity, Arterial Stiffness Index, Pulse Pressure and Pulse Pressure Index

目的:比较脉压、脉压指数、血管硬化指数和脉搏传导速度在临床上的应用。方法:88例经冠脉造影证实的冠心病患者和32例有同样传统心血管危险因素但冠脉造影结果阴性的患者。分别用Complior SP测量系统测定脉搏传导速度(PWV),用Cardiovision MS-2000测定血管硬化指数(ASI)。结果:两组患者除了年龄和吸烟史外,在性别和其它传统心血管危险因素上无明显区别。单因素分析示冠心病患者的脉压、脉压指教、C-F PWV和ASI均高于非冠心病患者,但多因素Logistic逐步回归分析发现冠心病患者与C-F PWV(β=0．409,P=0．003,EXP[β]=1．505)的相关性最为显著,并且在年轻冠心痛患者中只观察到C-F PWV值有显著升高(P=0．004)。结论:脉压、脉压指数、血管硬化指数和脉搏传导速度均与冠脉粥样硬化的存在有关。但在年轻冠心病患者预测价值上脉搏传导速度可能要优于其它3个指标。

Objective：To compare the clinical application of pulse wave velocity（PWV）,arterial stiffness index （ASI）, pulse pressure（PP）, and pulse pressure index（PPI）. Methods： 88 patients with angiographic prove of coronary artery disease and 32 matched individuals without coronary artery disease but having one or more conventional cardiovascular risk factors were included in the study. PWV was measured non-invasively using Complior SP. And arterial stiffness index was measured by Cardiovision MS-2000. Results： There was no significant difference in gender and the other presence of cardiovascular risk factors in the two groups except for ages and smoke. In univariate analysis, PWV, ASI,PP and PPI were all significantly higher in the coronary artery disease patients as compared to patients without coronary artery disease （all P〈0. 05）. But in Logistic multivariate analysis, only PWV was correlated with CAD（β= 0. 409, P = 0. 003, EXP（β） = 1. 505）. Further more, only a higher PWV was observed in younger CAD patients （〈 60 years）. Conclusion： Pulse wave velocity, arterial stiffness index, pulse pressure, and pulse pressure index were all higher with presence of coronary atherosclerosis. Maybe PWV is superior to other three indexes on prediction of younger CAD patients.