复方甘草酸酐对慢性乙肝患者T细胞亚群及白细胞介素的影响

The Stuty of the Influence of Glycyrrhizin to T-Lymphocyte-subsetes, Interleukin in the Patients with Chronic Hepatitis B

目的:探讨复方甘草酸酐注射液(美能)对慢性乙型肝炎患者T细胞亚群及白细胞介素IL-6、IL-8的影响。方法:对56例慢性乙型肝炎患者,静脉点滴美能注射液60-80 ml,治疗前后分别检测肝功能、T细胞亚群、IL-6及IL-8。结果:对照组ALT复常率为72．8％,治疗组ALT复常率为95．7％,明显高于对照组(P<0．05)。T细胞亚群检测显示治疗组经治疗后,CD4+、CD4+／CD8+明显升高(P<0．01),CD8+明显下降(P<0．05)。治疗组经治疗后,IL-6及IL-8明显下降(P<0．01)。结论:美能注射液治疗慢性乙型肝炎,不仅能改善T细胞功能,而且也能调节细胞因子。

Objective.. To study the influence of glycyrrhizin to T-lymphocyte-subsetes, IL-6 and IL-8 in the patients with chronic hepatitis B. Methods.. 56 cases of the hepatitis B were treated with glycyrrhizirk T-lymphocyte-subsetes, IL-6 and IL-8 were diterminded before and after the treatment. Results： The recovery rate of ALT was 95.7% in the study group, it was significantly higher than which in normal controls（P〈0. 05）. CD^4 ＋ , the ration of CD^4 ＋/CD^8 ＋ rose obviously（P〈0. 01 ） and CD^8 ＋ descended obviously（P〈0. 05） in the study group. There was no change in normal control group （P〉0. 05）. The levels of IL-6 and IL-8 descended obviously in the study group（P〈 0.01 ）. Conclusion： The results indicated that glycyrrhizin could improve both the immunologic function and interleukin in the patients with chronic hepatitis B.