脑钠素与急性心肌梗死患者临床表现的相关性研究

Relationship Between Plasma Brain Natriuretic Peptide Concentration and Clinical Feaures of Acute Myocardial Infarction

目的观察血浆脑钠素水平与急性心肌梗死面积、左室功能及预后的关系。方法选取63例确诊为急性心肌梗死的病人,入院后进行常规检查且24小时后测血浆BNP浓度,1周后检查超声心动图测左室射血分数(LVEF),随访3个月,观察血浆脑钠素浓度与心肌梗死的面积、左室功能及预后的关系。结果血浆BNP水平与心肌梗死面积呈正相关(P<0.01),与LVEF呈负相关(P<0.05),且血浆BNP高的病人心血管事件发生率高(P=0.02)。结论血浆脑钠素浓度反映了心肌梗死的严重程度,心肌梗死面积越大、左室功能越差,脑钠素的水平越高,且脑钠素可作为心血管病的预测指标。

OBJECTIVE To study the association between the plasma concentration of brain natriuretic peptide and severity, left ventricular function, prognosis in patients with acute myocardial infarction （AMI）. METHODS Sixty-three patients with acute myocardial infarction were enrolled in this study. The plasma concentration of BNP were measured at 24 hours after infarction. The infarction areas were measured according to the electrocardiogram, Left ventricular function was evaluated by echocardiography with the parameters of left ventricular ejection fraction （LVEF） after one week. Patients were followed up for three months, and their main adverse cardiac events （angina pectoris, sudden death et al） in patients of AMI were observed. RESULTS The concentration of BNP in patient with AMI was related with severity of the disease, the BNP increasd （P〈0.01）, with the enlargement of infarction areas while with the decrease of LVEF, the BNP increased （P〈0.05） . The development of any clinical main adverse cardiac events （depth/CHF/reinfarction） occurred more frequently in patients with a higher plasma BNP level （P=0.02）. CONCLUSION Plasma concentration of BNP in patients with AMI might be a reliable biochemical marker for predicting the severity and prognosis of this disease,