新疆Kaposi肉瘤12例免疫电镜观察

FⅧRAg、FN、TypeⅣColagen、HLA-DRandCMVAntigensinLesionsofKaposi′sSarcoma:AnImmuneElectronMicroscopicStudy

用第８因子相关抗原（ＦⅧＲＡｇ）、纤维连接蛋白（ＦＮ）、Ⅳ型胶原、ＨＬＡ－ＤＲ抗原和巨细胞病毒抗原（ＣＭＶ）５种标记抗体，对１２例新疆Ｋａｐｏｓｉ肉瘤（ＫＳ）瘤组织进行了免疫电镜观察。结果表明，ＫＳ组织内ＦⅧＲＡｇ、ＦＮ及Ⅳ型胶原均有阳性表达，特别是ＦⅧＲＡｇ主要见于明细胞内，暗细胞极少，ＦＮ在明、暗两种瘤细胞及间质中均可见到，Ⅳ型胶原主要见于少数基膜上，这一结果进一步证明ＫＳ虽是一血管肿瘤，但可能不是单一的内皮起源，而是起源于血管内皮和周细胞的观点。同时在１２例ＫＳ组织内均见有ＣＭＶ和ＨＬＡ－ＤＲ抗原的胶体金颗粒沉积，而作为对照的８例白癜风皮损除在真皮浅层见有少数树突状ＨＬＡ－ＤＲ阳性细胞外，ＣＭＶ抗原均为阴性。

TheauthorshaveexaminedthepresenceanddistributionoffactorⅧrelatedantigen(FⅧRAg),fibronectin(FN),typeⅣcolagen,HLA-DRandCMVantigensinthelesionsofKaposi′ssarcomabyimmuneelectronmicroscopicmethod.TheresaltsshowedthatFⅧRAg、FNandtypeⅣcolagenwereobservedinthelesionsofKaposi′ssarcoma.Intwotumorcels,theFⅧRAgwasfre-quentlyfoundinlightcelsshowingcytologiccharacteristicofendothelialcelsbutnotinthedarkcels,probablyofpericyticorigin.TheresultssuggestthatKaposi′ssarcomaisnotofpureendothelialoriginbutisderivedfrombothbloodvesselendothelialcelsandpericyticcels.TheHLA-DRandCMVanti-genswerealsoobservedinaltissuesofKaposi′ssarcoma,butCMVantigenswerenotobservedin8casesofvitiligoskin.TheresultssuggestthatCMVinfectionmightplayaroleinthedevelopmentofKaposi′ssarcoma.