激光心肌血管重建术对急性心肌缺血的保护作用

ProtectiveEffectofTransmyocardialLaserMyocardialRevascularizationonAcuteIschetnicMyocardi-um

本实验旨在研究激光心肌血管重建术对急性心肌缺血犬的近期影响与机制。１６只犬随机等分为对照组和实验组，用Ｎｄ：ＹＡＧ激光于缺血区心肌打孔，功率１５～１６Ｗ，３～４孔／ｃｍ￣２。结果（１）对照组４只犬死于顽固性室颤或心肌收缩无力，左前降支（ＬＡＤ）区心肌放射性分布明显稀疏或缺损，心肌细胞线粒体多重度损害（ＦｌａｍｅｎｇⅢ－Ⅳ级）。（２）实验组５例室颤，仅１例意外死亡，ＬＡＤ区有不同程度放射性分布，线粒体损伤较轻（Ｆｌａｍｅｎｇ０－Ⅰ级）。结论为激光心肌血管重建术对急性缺血心肌有保护作用。

ThepurposeofthisexperimentistostudytheearlyeffectsofTMRonAMIindogs.Method:16dogswereequallydividedintocontrolandexperimentalgroupsatrandom.lntheischemiczone,producedbyligationofLAD,transmuralchannels,3-4holes/cm2,werecreatedbyNd:YAGlaserwithlaserpowerof15-16W.Results,(1)lnthecontrolgroup,4dogsdiedofrefractoryventricularfib-rillation(VF)orcardiacamyotonia.lntheexperimentallyproducedischemicarea,scarcityofdefectofradioactiveisotopicdistributionwasobvious,andinjuryofthemitochondriainthemyocardialcellswasverysevere(FlamengⅢ-Ⅳ).(2)lntheexperimentalgroup,5dogsdevelopedVFandonediedac-cidentally.lntheischemicarea,theradioactiveisotopicdistributionvariedtosomeextent.lnjuryofthemitochondriaofthemyocardialcellswasmild(Flameng0-I).Conclusion:TheresultsofthisstudysuggestthatTMRhasprotectiveeffectontheacuteischemicrnyocardium.