摘要
研究Ｎｄ：ＹＡＧ激光对缺血心肌直接血管重建术的远期效果。结扎犬冠状动脉左前降支建立动物模型后，实验组用Ｎｄ：ＹＡＧ激光在左室壁中心缺血区打孔２０－２５个，孔间距５－１０ｍｍ；对照组不行激光打孔，８个月后行放射性核素心肌扫描、左室造影及左心功能测定。结果显示心肌核素扫描实验组仅１例有心肌缺血，４例正常；对照组５例均示左室前壁严重心肌缺血（Ｐ＜０．０１）。左心室造影实验组２例显示左室的壁运动减弱，其余３例正常；对照组５例均显示左室前壁及尖部室壁瘤形成。左心功能测定显示总体射血分数、节段射血分数（２ＡＥＦ．３ＡＥＦ）、左室短轴径缩短率实验组均高于对照组（Ｐ＜０．０５、０．０５、０．０１、０．０５），ＬＶＳＰ、＋ｄｐ／ｄｔｍａｘ、－ｄｐ／ｄｔｍａｘ则高于对照组（Ｐ＜０．０１、０．０５、０．０５），ＬＶＥＤＰ两组无差异。实验结果说明应用Ｎｄ：ＹＡＧ激光贯穿室壁对缺血心肌直接血管重建术能改善缺血心肌的血供。
Thelong-termefficacyoftransmyocardialrevascularizationonischemicareabyNd:YAGlaserwasstudiedoncanitneheartmodels.Tennormalmongreldogsweredividedintotwogrottps:experimentalgroup(EG.n=5)andcontrolgroup(CG,n=5).Nd-YAGlaserwasusedtocreate20-25transmyocardialchatnnels5mm-10mmapartfromeachotherintheischemicareaofanteriorwallofleftventricleinEG.NochannelwasmadeinCG.Theleftanteriordescendingbranchofcoronaryarteryindogsofbothgroupswasligated.Aftereightmonths,themyocardialradioisotopicscanningwasper-formedandleftventriclefunctionwasmeasured.ResultsMyocardialradioi.otopicscanningshowedobvi-oustransmuralinfarctioninalldogsofCG,butinonlyonedogofEG.(P<0.01)Leftventricularcineangingraphydemonstratedweakmotionofanteriorwallof1.Vintwodogsbutnormalintheother3ofEG.However,inCG,akinesisoftheanteriorwallofleftventriclewasdetectedinalldogs.Leftven-tricularfunctionshowedthatthetotalejectionfraction(TEF),areaejectionfraction(2AEF,3AEF)andshortdiametershorteningrate(△D)ofleftventricleinEGwererespectivelyhigherthanthoseinCG(P<0.05,P<0.05,<0.01,<0.05),andLVSP,+dP/dtmax.-dP/dtmaxinEGwerealsohigherthantherespectivevaluesinCG(P<O.01,P<0.05,P<0.05).TheresultsofthisstudysuggestthatNd:YAGlaserwasefficaciousfortratns-myocardialrevascularization.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1996年第5期270-272,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
