复方甘草酸苷联合拉米夫定治疗慢性乙型肝炎的临床研究

Combination treatment of chronic hepatitis B with strongerneo-minophagen C (SNMC) and lamivudine

[目的]观察复方甘草酸苷对慢性乙型肝炎患者血清病毒学标志的影响．[方法]采用复方甘草酸苷联合拉米夫定治疗30例慢性乙肝患者,并与30例拉米夫定单药治疗患者比较,观察治疗后血清病毒学标志及肝功能指标的变化．[结果]治疗12周时联合治疗组血清HBeAg／抗-HBe转换率明显高于对照组；治疗12周和24周时联合治疗组肝功能指标复常率明显高于对照组．[结论]复方甘草酸苷治疗慢性乙型肝炎可能有助于患者在拉米夫定治疗过程中早期发生HBeAg／抗-HBe血清转换．

[ Objective ] To observe the effects of stronger neo-minophagen C （SNMC） on HBV virological markers in patients with chronic hepatitis B. [ Methods] Sixty patients with chronic hepatitis B were included in this study. Thirty of them were treated with SNMC and lamivudine concomitantly, and the others were treated with lamivudi- ne only. The HBV markers and liver function parameters were monitored during the treatment. [ Results] HBeAg/ anti-HBe seroconversion rate was significantly higher in the combination group than in the controls after 12 weeks＇ treatment. The normalization for liver function parameters were significantly higher in the combination group than in the controls after 12 weeks＇ and 24 weeks＇ treatment. [ Conclusions] SNMC treatment may be helpful to HBeAg/ anti-HBe seroconversion in chronic hepatitis B patients when combined with lamivudine.