3种甘草酸苷对慢性乙肝患者血糖及肝功能病毒影响的临床研究

Clinical research that three kinds of Glycyrrhizin to chronic B liver sufferer's blood sugar and liver function viruses affect

[目的]了解甘草酸苷对慢性乙肝患者血糖的影响.[方法]把95例确诊为慢性乙型肝炎的患者随机分为A、B、C三组,分别给予复方甘草酸苷80 m l、复方甘草酸单铵120 m l、甘草酸二铵40 m l静脉点滴,用药前、用药2周及4周观察三组患者的空腹血糖、肝功能、HBVM、HBV-DNA定量.[结果]治疗前三组患者空腹血糖的均数分别为5.28±1.75、5.32±1.66及5.65±1.82 mmol/L,在用药2周时,三组患者空腹血糖的均数即已有所下降,至用药4周其空腹血糖的均数分别为4.5 1±1.6 5、4.6 8±1.3 7及4.9 8±1.87 mmol/L,与治疗前相比三组患者空腹血糖的均数都有不同程度下降,但治疗前后的差异无显著性(P>0.05),各组之间下降的差异亦无显著性(P>0.05).[结论]甘草酸苷对慢性乙肝患者的血糖没有升高作用,反而在一定剂量下有降低的作用.

[ Objective] To investigate the effect of Glycyrrhizin on blood sugar in HBV patients. [ Methods ] Ninety-five HBV patients were randomly divided into group A,group B and group C,which were treated with intravenous Compound Glycyrrhizin （80 ml） ,Compound Ammonium Glycyrrhetate（ 120 ml） and Diammonium Glycyrrhizinate（40 ml） respectively. The fasting blood sugar,liver functions ,HBVM and HBV-DNA were measured, respectively before the administration and after the corresponding treatments for 2 weeks and 4 weeks. [ Results] The level of fasting blood sugar before treatment were 5.28±1.75 mmol/L,5.32±1.66 mmol/L and 5.65 ± 1.82 mmol/ L respectively. After treatments for 2 weeks, the level of fasting blood sugar in each group initially decreased. After treatments for 4 weeks ,the level of fasting blood sugar were 4. 51 ± 1.65 mmol/L,4. 68 ± 1.37 mmol/L and 4.98 ± 1.87 mmol/L,which were decreased to some extent in contrast to the pre-treatment period. However, there were no significant difference between pre-treatments and pest-treatments as well as the decreasing level（ P 〉 0. 05 ）. [ Conclusion] The level of blood sugar was not increased by Glycyrrhizin in the HBV patients ,however,decreased by some dose of Glycyrrhizin.