氯胺酮诱导的大鼠条件性位置偏爱

KETAMINE INDUCES RAT CONDITIONED PLACE PREFERECE

目的:探讨氯胺酮在大鼠模型上形成条件性位置偏爱(CPP)的特点,分析氯胺酮精神依赖性潜力。方法:(1)60只SD♂大鼠随机分为对照组、氯胺酮及吗啡阳性对照组。(2)氯胺酮组每隔24h腹腔注射氯胺酮10m·lkg-1一次,连续6d,建立大鼠氯胺酮精神依赖性模型,吗啡组给予等剂量的吗啡,对照组则给予等剂量的生理盐水;(3)氯胺酮组及吗啡组于CPP形成后给予生理盐水进行消退实验。结果:(1)氯胺酮组及吗啡组大鼠出现了明显的CPP;(2)与吗啡组相比,氯胺酮组的CPP效应更显著,但消退较快。结论:氯胺酮可诱导大鼠产生CPP,但随着时间的推移CPP消退速度较吗啡快。

Objective： To investingate the potential of different ketamine in the formation of conditioned place preference （CPP）. Methods： （1） 60 Sprague- Dawlay rats were randomly divided into three groups for saline control, ketamine and morphine treatment. （2） Ketamine and morphine were administrated at 10 ml. kg^-1 by intraperitoneal injection once a day for 6 days for induction of CPP in the three - chamber apparatus. （3） The formation and extinction of CPP were determined on dl and d10 after drug conditioning. Results： Ketamine induced a significant rat CPP. Ketamine - induced CPP was extinct more rapidly than that of morphine. Conclusion： Ketamine can induce rat conditioned place preference implying a physiological dependence potential.