老年人9种性激素的化学发光免疫分析

Chemoluminescence immunoassay of nine reproductive hormones in the elderly

目的探讨9种性激素在老年人中的变化。方法应用全自动微粒子化学发光免疫分析对180例老年人进行血清促黄体生成激素(LH)、促卵泡生成激素(FSH)、雌二醇(E2)、泌乳素(PRL)、孕酮(P)、17α-羟基孕酮(17α-OHP)、睾酮(T)、硫酸去氢表雄酮(DHEA-S)、雄烯二酮(A2)等9种性激素含量测定。结果绝经妇女的性激素水平较之育龄妇女有明显差别(P<0.001)。除LH和FSH呈高水平外,其他激素均明显低下,其中27例(59.4%)的E2接近零。成人男性组的E2、P、PRL和A2较女性为低,T、DHEA-S则高于女性;FSH、LH、17α-OHP近似女性女性卵泡期水平。老年男性组性激素水平与成年男性组比较略有差异。结论健康妇女绝经后性激素水平有显著的变化,老年男性与成年男性之间性激素水平略有差别。本研究提供了老年人9种性激素正常参考值。

Objective To explore the changes in nine sex hormones levels in the elderly. Methods Serum levels of nine sex hormones including luteotrophic hormone （LH）, follicle-stimulating hormone （FSH）, prolactin （PRL）, estradiol （E2 ）, progestone（P）, testosterone （T）, 17α-hydroxyprogesterone （17α-OHP）, dehydroepiandrosterone sulfate （DHEA-SO4）, andrestenedione （A2）,were measured in 97 elderly by fully auto micreparticle chemiluminescence immune assay. Results Serum levels of sex hormones in menopausal women were significantly lowered （P 〈0.001 ） except LH and FSH, and E2 levels in 21 women were nearly undetectable. E2, P and PRL levels of the males were lowered than those of the females ,but T and DHEA-SO4 levels were higher and FSH,LH and 17α-OHP were similar to those of the women in follicular phase. There was slight difference in sex hormones between elderly male and adult male. Conclusions The sex hormone levels in healthy postmenopausal women have significant changes, while those in elderly male have slight difference, providing the normal reference values of nine sex hormones in the elderly.