老年人血清瘦素浓度与糖尿病肾病的相关性研究

Association between serum leptin concentration and type 2 diabetic nephropathy in the elder patients

目的研究老年人血清瘦素(Leptin)浓度与糖尿病肾病(DN)的相关性。方法应用酶联免疫法测定62例DN患者血清瘦素浓度。结果①肥胖者血清瘦素水平高于非肥胖者(P<0.001);②血清瘦素水平在不同性别间差异显著,女性高于男性(P<0.001);③DN(+)组肥胖者血清瘦素水平为(14.85±5.45)ng/m l,非肥胖者为(7.13±2.77)ng/m l,DN(-)组肥胖者血清瘦素水平为(11.01±4.04)ng/m l,非肥胖者为(5.12±2.86)ng/m l。DN(+)组与DN(-)组比较,瘦素浓度差别具有显著性(P<0.01);④采用Logistic逐步回归分析发现血清瘦素浓度、尿白蛋白排泄率、高血压、高血糖、脂代谢紊乱等为DN的危险因素。结论血清瘦素浓度升高增加了老年人DN发生的危险。

Objective To investigate the relationship between serum leptin concentration and type 2 diabetic nephropathy （DN） in elder patients. Methods Serum leptin concentrations were measured by enzyme-linked immunosorbent assay in 128 （65 male and 63 female） DM patients, including 62 cases with DN. Results①The fast serum leptin concentrations in the obese were higher than that of the nonobese （P 〈0.001 ）. ②Serum leptin concentrations in the female were higher than that in the male （P 〈 0.001 ）.③The serum leptin concentrations in obese DN（ ＋ ） group, nonobese DN（ ＋ ） group, obese DN（ - ） group and nonobese DN（ - ） group were respectively （ 14.85 ± 5.45 ）, （7.13 ± 2.77 ）, （ 11.01 ± 4.04 ）, （ 5.12 ± 2.86 ） ng/ml. There was significant difference in serum leptin concentration between DN（ ＋ ） group and DN（ - ） goup （P 〈0.01 ）. ④The logistic regression analysis showed that serum leptin concentration, urinary albumin excretion rate （UAER）, hypertension, hyperglycemia and lipid metabolic disorder were the dangerous factors for DN. Conclusions The increased serum leptin concentrations could enhance the risk for development of DN in elder patients.