密蒙花黄酮类化合物的分离和鉴定

SEPARATION AND IDENTIFICATION OF THE FLAVONOIDS FROM BUDDLEIA OFFICINALIS MAXIM

从密蒙花（ＢｕｄｄｌｅｉａｏｆｆｉｃｉｎａｌｉｓＭａｘｉｍ）的花蕾中分离得到８个黄酮类化合物，其小３个甙元：刺槐素（ａｃａｃｅｔｉｎ，１），芹菜素（ａｐｉｇｅｎｉｎ，２），木犀草素（ｌｕｔｅｏｌｉｎ，３）；５个甙：密蒙花新甙（ｎｅｏｂｕｄｏｆｆｉｃｉｄｅ，４），蒙花甙（ｌｉｎａｒｉｎ＝ａｃａｃｉｉｎ，５），木犀草素７－Ｏ－芸香糖甙（６），木犀草素－７－Ｏ－葡萄糖甙（７），秋英甙（ｃｏｓｍｏｓｉｉｎ，８）。化合物４为新化合物，用化学和波谱法确定其结构为５．７－二羟基－４＇－甲氧基黄酮－７－Ｏ－α－Ｌ－吡喃鼠李糖基－（１→２）－［α－Ｌ－吡喃鼠李糖基－（１→６）］－β－Ｄ－吡喃葡萄糖甙，除化合物１和５以外，其它化合物均为首次从密蒙花中得到。

The flowers of Buddleia officinalis Maxim have been used to cure eyeinflammation in China.Eight flavonoid compounds were isolated from them.Their structures werecharacterized as acacetin(1),apigenin(2),luteolin(3),neobudofficide(4),linarin(5,acaciin),luteolin-7-O-rutinoside(6),luteolin-7-O-glucoside(7)and cosmosiin(8),on the basis of chemicaland spectral evidences.The new compound 4 was identified as 5,7-dihydroxy-4'-O-methoxyflavone-7-O-α-L-rhamnopyransoyl(1→2)-[α-L-rhamnopyranosyl(1→6)]-β-D-glucopyranoside and namedneobudofficide.All the compounds were isolated from B.officinalis for the first time,except linarinand acacetin.