摘要
苄基四氢巴马汀对表达于非洲爪蟾卵母细胞及中华大蟾蜍卵母细胞的延迟整流钾电流的抑制作用童秋生，夏国瑾，姚伟星，江明性，白小川，包永德（同济医科大学基础医学院药理学教研室，武汉４３００３０；中国科学院上海生理学研究所，上海２０００３１）苄基四氢巴马汀（ｂ...
The effects of benzyltetrahydropalmatine(BTHP)on delayed rectified K+currents(Ik)expressed in Xenopus cocytes and Ik of toad(Bufo bufo gargarizans)cocytes were studied.The Ikexpressed in Xenopus oocytes was measured after microinjection of mRNA isolated from carp fish(Canratus L.)brains with double-microelectrode voltage clamp technique.The maximum and meanvalue of Ik expressed in Xenopus oocytes were 600 nA and 360±104 nA,respectively.BTHP reducedthe current amplitude of Ik expressed in Xenopus cocytes in 10～1000 μmol·L-1 dose-dependently,EC50 was 29μmol·L-1.Also,the reduction of Ik of toad oocytes was 9.1%,29.1%,54.7% and68.6% by BTHP 10,30,100 and 1000μmol·L-1,respectively,EC50 was 33μmol·L-1,Theresults showed that BTHP possesses an inhibitory effect on Ik,the main ion mechanism ofantiarrhythmic action of BTHP.
出处
《药学学报》
CSCD
北大核心
1996年第11期867-871,共5页
Acta Pharmaceutica Sinica
关键词
苄基四氢巴马汀
钾通道阻滞剂
抗心律失常药
Benzyltetrahydropalmatine
Potassium channel
Voltage clamp
mRNA expression
