摘要
以沙土鼠单侧结扎颈总动脉造成单侧脑水肿病理模型，观察了两种蛋白激酶Ｃ（ＰＬＣ）抑制剂１－（５－异哆琳磺酞基）－２－甲基哌嗪（Ｈ－７）及苦参碱（Ｍａｔ）对实验性脑缺血所致的脑水肿的影响，结果表明：缺血前３０ｎｉｉｎｌｐＨ－７（６．２５和１２．５ｒｎｇ·ｋｇ－１）可有效减轻沙土鼠单侧结扎颈总动脉７ｈ所致的结扎侧脑半球的水肿程度，同时减少该侧脑半球电解质的蓄积；Ｍａｔ（２５和５０ｍｇ·ｋｇ－１）对沙上鼠单侧结扎颈总动脉７６以及ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠中动脉阻塞ｌｈ后再灌流２４ｈ所致的脑水４中均有防治作用。
Recent studies have suggested that protein kinase C(PKC)may be involved in thefoimation of brain edema.In this paper,the effects of two kinds of PKC inhibitors,H-7 and matrine,were examined on the brain edema formation in experimental models.The resuIts showed thatpretreatment with H-7 6.25 and l2.5mg·kg-1 prevented the accumulation of water and certainelectrolytes in the unilateral hemisphere of the brain evoked.by ligation of a single common carotidartery in Mongolian gerbil; pretreatment with matrine 25 and 50 mg·k-1 reduced the extent ofcerebral edema foimation evoked by ligation of a single common carotid artery in gerbil and by middlecerebral artery occlusion in Sprague-Dawley rats.These resuIts present new evidence for theinvolvement of PKC in the formation of brain edema.
出处
《药学学报》
CAS
CSCD
北大核心
1996年第12期886-890,共5页
Acta Pharmaceutica Sinica
关键词
蛋白激酶
脑缺血
脑水肿
Protein kinase C
1-(5-isOquinolinylsulfonyl)-2-methylpiperazine
Matrine
Cerebralischemia
Brain edema
