摘要
合成了20个O,O’-二烷基-O-”-(取代苯乙睛肟)磷酸酯、硫代磷酸酯,并分别与杀螺剂氯硝柳胺组成复方,进行室内杀螺试验,初步结果表明,化合物V4、7、12、18有明显杀螺增效作用,其中V12可使氯硝柳胺的杀螺效果提高3.8l倍。同时发现化合物V2、10、13单独使用时,也有良好的杀螺作用。
Twenty compounds of O,O' -dialkyl-O'-(substituted phenylglyoxylonitrileoximino) phosphates and thiophosphates were prepared.The screening tests showed that compoundsV4,7,12,18 combined with niclosamide exhibited significant molluscicidal synergism against snails(Oncomelania hupensis hupensis).The LC50 of niclosamide alone and V12 combined with niclosamide(1:1)against snail was 0. 0820 mg·L-1 and 0.0215 mg·L-1,respectively. The molluscicidalactivity of the latter was 3.81 times that of niclosamide alone.The compounds V2,7, 10,13 appeared tohave high molluscicidal activity.
出处
《药学学报》
CAS
CSCD
北大核心
1996年第12期918-924,共7页
Acta Pharmaceutica Sinica
基金
"八五"国家科技攻关项目
关键词
药物
磷酸酯
硫代磷酸酯
杀螺剂
氯硝柳胺
合成
Phosphate
Thiophosphate,Molluscicide
Synergistic activity
Niclosamide