高血压患者外周动脉疾病与血尿酸水平关系的研究

Study on Serum Uric Acid Levels in Relation with Peripheral Arterial Diseases in Hypertensive Patients

目的比较高血压合并外周动脉疾病与高血压不合并外周动脉疾病患者的血尿酸水平,探讨高血压患者外周动脉疾病与血尿酸水平的关系。方法北京及上海地区医院住院的4 415例明确诊断原发性高血压患者为研究对象,测量他们的踝臂指数,踝臂指数<0.90者诊断为外周动脉疾病(peripheral arterial disease,PAD)。将研究对象分为PAD组1 221例,非PAD组3 194例,测定其血脂及尿酸水平,对结果进行统计学处理。结果PAD组血尿酸水平(349.43±125.99μmol/L)明显高于非PAD组(327.24±110.29μmol/L)(P≤0.01),经logistic回归分析,显示尿酸水平与PAD相关(P≤0.01)。结论血尿酸水平和糖尿病史、吸烟史、性别一样是高血压患者合并外周动脉疾病的危险因素。

Objective To compare uric acid levels between patients with hypertension incorporated with peripheral artery diseases （PAD） and patients with hypertension only and investigate the relationship between uric acid level and PAD. Methods In 4415 cases of definitely diagnosed essential hypertension, ankle brachial index were measured and those whose ankle brachial index lower than 0.90 were diagnosed as PAD. Divided these cases into PAD group and non- PAD group respectively and their blood fat and uric acid levels were measured. Results Average uric acid level of PAD group （349.43 ± 125.99μmol/L） was significantly higher than that of non PAD group（327.24 ± 110.29μmol/L）. Logistic regression analysis indicated that uric acid level was correlated with PAD. Conclusion Uric acid level, history of diabetes, smoking and gender were risk factors of hypertension incorporated with PAD.