p14ARF在子宫内膜样腺癌组织中的表达及其意义

Expression of p14ARF Protein in Endometrioid Adenocarcinoma and its Clinical Significance

目的探讨p14ARF蛋白在子宫内膜样腺癌组织中的表达及其临床意义。方法应用免疫组化方法检测15例正常子宫内膜、18例子宫内膜增生及43例子宫内膜样腺癌组织中p14ARF蛋白的表达。结果p14ARF在正常子宫内膜、子宫内膜增生及子宫内膜样腺癌组织中的阳性表达率分别为93.3%、83.3%及55.8%。与正常子宫内膜组及子宫内膜增生组比较,子宫内膜样腺癌组织中p14ARF的阳性表达率明显下降(P<0.05);p14ARF在G3级和G2级子宫内膜样腺癌中的表达低于G1级的子宫内膜样腺癌(P<0.05)。结论p14ARF表达异常可能与子宫内膜样腺癌的发生、发展有关。

Objective To investigate the expression of p14ARF protein in endometrioid adenocarcinoma and its clinical significance. Methods The expression of p14ARF protein was detected by immunohistochemistry in 15 normal endometrium tissues, 18 endometrial hyperplasia tissues, and 43 cases endometrioid adenocarcinoma tissues. Results The positive rate of p14ARF in nor- mal endometrium , endometrial hyperplasia, and endometrioid adenocarcinoma were 93. 3%, 83.3 %, and 55.8%, respectively. As compared with that in normal endometrium and endometrial hyperplasia, the expression of pl4ARF proteins was reduced in endometrioid adenocarcinoma（P〈 0.05）. The positive expression rates of p14ARF protein in poorly and middling differentiated en- dometrioid adenocarcinoma were lower than that in highly differentiated endometrioid adenocarcinoma（P〈0. 05）,but was not associated with other clinicopathological parameters（P〈0. 05）. Conclusion The variation of p14ARF expression in endometrioid adenocarcinoma, might contribute to the occurrence and development of the cancer.