焦虑症患者的血浆单胺类神经递质及相关因素研究

The study of plasma monoamine neurotransmitters and related factors in anxiety neuroses

目的:探讨血浆单胺类神经递质与焦虑症的关系及影响血浆单胺类神经递质浓度的因素。方法:使用高效液相-电化学检测法测定20例焦虑症患者和21例正常人的血浆去甲肾上腺素(NE)和五羟色胺(5-HT)浓度。结果:焦虑症患者的血浆NE浓度[(0.83±0.71)ng/mL]显著高于正常对照组[(0.45±0.29)ng/mL](P<0.05),焦虑症组的血浆5-HT浓度[(89.80±54.28)ng/mL]与正常对照组[(145.62±86.02)ng/mL]相比差异无显著性(P>0.05)。多元逐步回归分析结果显示,影响血浆NE浓度的因素有性别(P=0.047)、是否急诊(P=0.034)和起病形式(P=0.042);影响血浆5-HT浓度的因素有性别(P=0.024)、显效时间(P=0.025)、A型行为问卷总分(TH+CH)(P=0.008)、TH分(P=0.010)和CH分(P=0.006)。结论:焦虑症患者存在血浆NE浓度的异常,血浆单胺类神经递质受到多种因素的影响。

Objective： To explore plasma monoamine neurotransmitters and its correlative factors in anxiety. Methods： The plasma NE and 5 - HT levels were measured in 20 anxiety patients and 21 controls by high performance liqnid chromatography （HPLC） with electrochemical detection. Results： The plasma NE levels of anxiety patients were significantly higher than those in control group[ （0.83 ± 0.71 ） ng/mL vs （0.45 ± 0.29 ） ng/mL ,P 〈 0.05 ]. There were no significantly differences between two patient groups in the plasma 5 - HT level [ （ 89.80 ± 54.28 ） ng/mL vs （ 145.62 ± 86.02 ） ng/mL, （ P 〉 0.05 ） 1- Multiple - stepwise regression analysis indicated that the plasma NE level was inilueneed by sex （ P = 0. 047 ） , emergency or not （ P = 0. 034 ） , form of onset （ P = 0.042 ）. The plasma 5 - HT level was influenced by sex （ P = 0. 024 ）, effectual time （ P = 0. 025 ） , the total score of TABQ （ P = 0. 008 ）, TH factor score （ P = 0. 010） , CH factor score （ P = 0. 006）. Conclusions ： The results suggest that the dysfunction of plasma NE levels is involved in anxiety neuroses. Plasma monoamine neurotransmitters are influenced by multi -factors.