异丙醇-水为溶剂合成西草净

Simetryne synthesis using isopropanol-water as solvent

以三聚氯氰、乙胺和甲硫醇钠为原料,以50%异丙醇+50%水为溶剂(v)制备了西草净。讨论了原料配比、反应时间和反应温度等因素对反应的影响,获得了较佳的反应条件。较佳反应条件为三聚氯氰∶乙胺∶氢氧化钠∶甲硫醇钠=1∶2.1∶2.0∶1.7(mol),第一、第二、第三取代反应的反应温度和反应时间分别为-2℃、0℃、82℃和30、60、180min。在较佳的反应条件下,西草净的收率和纯度分别为80.1%和95.2%。

Simetryne was synthesized from cyanuric chloride, ethylamine, and sodium methyl mercaptide in a 50% （by vol） isopropanol ＋ water solution. Effects on the reaction of factors such as reactant ratio, reaction time, and reaction temperature were investigated, and optimum reaction conditions were determined as follows： mole ratio of cyanuric chloride to ethylamine to sodium hydroxide to sodium methyl mercaptide was 1：2.1：2.0：1.7, and the temperature and time of the first, second, and third substitution reactions were -2, 0, and 82% and 30, 60, and 180 min, respectively. Under optimum reaction conditions, yield and purity of simetryne was 80.1% and 95.2%, respectively.