前列腺素 E_2在念珠菌性阴道炎发病机理中的作用

The Role of Prostaglandin E_2 on Pathogenesis of Candidal Vaginitis

为了探讨前列腺素 E_2(PGE_2)在念珠菌性阴道炎发病机理中的作用,我们观察了白念珠菌及组胺对正常人及念珠菌性阴道炎患者外周血单一核细胞产生 PGE_2的影响,PGE_2对白念珠菌芽管形成及粘附力的影响。结果发现白念珠菌及组胺具有协同刺激作用,使 PGE_2的产生大幅度提高。PGE_2能促进白念珠菌芽管形成,增加其粘附力,从而增强了白念珠菌致病力。上述结果显示 PGE_2在念珠菌性阴道炎发病机制中起了一定作用。

In order to study the role of prostaglandin E2(PGE_2)on the pathogenesis of candidal vaginitis,the effect of Candida albicans and histamine on the production of PGE_2 by peripheral blood mononuclear cells from patients with candidal vaginitis and normal controls,the effect of PGE2 on germ tube formation of Candida albicans,and the effect of PGE2 on Candida albicans adhering to vaginal ep- ithelial cells were observed.The results showed that:Candida albicans and histamine induced PGE2 synergistically,and the production of PGE2 increased markedly.PGE2 enhanced germ tube formation in Candida albicans,increased the number of Candida albicans adhering to the vaginal epithelial cells, and the pathogenicity of C.albicans.The above results indicate that PGE_2 plays a role in the pathogene- sis of candidal vaginitis.