摘要
A water soluble hydroxy-capped comb-like poly(ethylene glycol)(CPEG) was prepared via atom transfer radical polymerization(ATRP).A stable CPEG coating was obtained via dip-coating followed by curing at 70℃ for 48 h.The CPEG-modified surface was proved to be stable in both aqueous environment and ambient according to contact angle behavior and weight decrement testing.The coating forming mechanism was investigated through FTIR,the spectra data demonstrated the stability of CPEG coating derived from its hydrogen bond of inter-molecules and intra-molecules.Platelet experiment showed CPEG modified surface reacted extremely weakly with platelet and showed excellent thrombus resistance than that of both on the pure PET surface and PET surface modified with linear PEG.The model drug RD6G was applied to fabricate a drug-buried CPEG coating surface.The drug-releasing curve demonstrated the stability of the CPEG coating and the controlled-release behavior of RD6G.The unique property of CPEG coating surface provided the potential application in the immobilization and release of aqueous drug,including protein and peptide.
A water soluble hydroxy-capped comb-like poly （ethylene glycol ） （CPEG） was prepared via atom transfer radical polymerization （ATRP） . A stable CPEG coating was obtained via dip-coating followed by curing at 70℃ for 48 h. The CPEG-modified surface was proved to be stable in both aqueous environment and ambient according to contact angle behavior and weight decrement testing. The coating forming mechanism was investigated through FTIR, the spectra data demonstrated the stability of CPEG coating derived from its hydrogen bond of intermolecules and intra-molecules. Platelet experiment showed CPEG modified surface reacted extremely weakly with platelet and showed excellent thrombus resistance than that of both on the pure PET surface and PET surface modified with linear PEG. The model drug RD6G was applied to fabricate a drug-buried CPEG coating surface. The drug-releasing curve demonstrated the stability of the CPEG coating and the controlled-release behavior of RD6G. The unique property of CPEG coating surface provided the potential application in the immobilization and release of aqueous drug, including protein and peptide.
出处
《高分子学报》
SCIE
CAS
CSCD
北大核心
2006年第5期703-706,共4页
Acta Polymerica Sinica
基金
国家自然科学基金(基金号50373036)
国家重点基础研究规划项目(973)(项目号2005CB623902)
教育部霍英东基金优选(项目号J20040212)资助项目
