根除幽门螺杆菌对胃黏膜及肠化、不典型增生的影响

The effect of Helicobacter pylori eradication on intestinal metaplasia and atypical hyperplasia of gastric mucosa

目的探讨根除幽门螺杆菌（Hp）后慢性胃炎的胃黏膜炎症及肠上皮化生、不典型增生的变化。方法选择172例伴有Hp感豢的慢性活动性胃炎病人分为两组：阴性组（68例）和阳性组（104例），观察阴性组治疗后的变化并与阳性组进行比较，并观察阴性组肠上皮化生和不典型增生在治疗前后的变化。结果阴性组的胃黏膜炎症有28例（41．2％）好转，2例（2．9％）治愈，明显高于阳性组（P〈0.01），其伴有的肠上皮化生有2例（25％）治愈，4例（50％）好转，不典型增生有7例（38．9％）好转，6例（33．3%）治愈。结论Hp感染阴转后慢性胃炎的治疗效果明显优于阳性者，其伴有的肠化和不典型增生亦能好转或治愈。因此，根除Hp是治疗Hp相关性胃炎和防止发生胃癌的重要措施。

AIM To explore the effects of Helicobacter pylori （Hp） eradication on gastric mucosa imflammation of chronic gastritis, the intestinal metaplasia and the atypical hyperplasia. METHODS 172 cases of chronic active gastritis with Hp infection were divided into two groups： Hp negative group（68 cases）and Hp positive group（104 cases）. To observe the change of the Hp negative group after treatment and to be compared with Hp positive group,especially to study the change of intestinal metaplasia and atypical hyperplasia in the Hp negative group after treatment. RESULTS In the negative group,28 cases（41. 2% ）were relieved and 2 cases （2.9%） were cured,much higher than that in Hp positive group（ P 〈0.01）,4 cases（50% ） were relieved and 2 cases（25% ）were cured in the intestinal metaplasia,7 cases（38.9% ）were relieved and 6 cases（33.3% ）were cured in the atypical hyperplasia. CONCLUSION The therapeutic effect of chronic gastritis in Hp negative group was much better than that in Hp positive group, the intestinal metaplasia and atypical hyperplasia would relieve or disappear, thus Hp eradication is an important measure to treat the chronic gastritis with Hp infection. Furthermore, it can prevent occuring gastric cancer.