肠上皮内淋巴细胞抗弓形虫感染的免疫功能研究进展

Progress on research of immunological function of intestinal intraepithelial lymphocytes against the infection of Toxoplasma gondii

刚地弓形虫(Toxoplasma gondii)经口感染后引发一系列免疫应答,包括先天性免疫和获得性免疫应答。某些近交系小鼠感染后肠道内稳态平衡的改变,导致急性回肠炎。肠道相关淋巴组织(gut-associatedlymphoid tissue,GALT)为抵抗弓形虫感染的首道屏障,肠上皮内CD4+T细胞分泌趋化因子和细胞因子来清除弓形虫,而肠上皮内CD8+T细胞分泌转化生长因子来减轻炎症反应。该文综述了经口感染弓形虫后,以肠上皮内淋巴细胞(intestinal intraepithelial lymphocytes,iIEL)为代表的GALT细胞群在抗弓形虫感染中的免疫功能特征。

Toxoplasma gondii, an intracellular parasite infects the host through the oral route. Infection induces a series of immunological events that involve both the innate and acquired immune responses. Alteration of the homeostatic balance of infected intestine results in acute ileitis in certain strains of inbred mice. Gut-associated lymphoid tissue is the important barrier to resist infection of Toxoplasma gandii. The intraepithelial CD4 T cells produce chemokines and cytokines that are necessary to eliminate the parasites whereas CDST intraepithelial lympbocytes secrete transforming growth factor that reduces the inflammation. In this review, we describe the features of immunological function of intestinal intraepithelial lymphocytes, as representatives of the gut-associated lymphoid tissue cell population, against the infection of Toxoplasma gondii after oral infection.