摘要
目的:观察电针对糖尿病性认知功能障碍患者学习记忆的改善作用,并与尼莫通作对照。方法:将45例符合诊断标准的患者随机分为电针组25例,对照组20例。电针组取四神聪、百会、风池、本神、内关为主穴,电针为疏密波,频率14~26次/min,强度3~5mA,每次治疗30min,每日1次,连续5d后休息2d,共6周。对照组口服尼莫通,每次30mg,每日3次,连续治疗6周。对两组治疗前后进行长谷111痴呆修改量表评分及韦氏记忆量表(wMs)评定。结果:两组疗效的差异具有显著性意义,电针组疗效优于对照组;治疗前两组WMS(总记忆商)无显著差异,P〉0.05,治疗后电针组WMS评分明显上升,P〈0.05,而对照组虽然也有上升,但不显著,P〉0.05。电针组治疗后WMS在顺数、联想、触摸方面有显著上升,P〈0.05;而对照组WMS在累加、触摸方面有显著上升,P〈0.05;其余各项两组均表现为治疗前后差异不显著,P〉0.05。结论:电针能改善糖尿病性认知功能障碍患者的认知功能和学习记忆能力。
Objective: To observe the effect of electroacupuncture (EA) on the learning and rnenory ability in diabetic cognitive dysfunction patients. Methods: Forty-five cases of diabetic mellitus (DM) patients with cognitive dysfunction were randomly divided into EA group (n=25) and medication group (n=20), For patients of EA group, main acupoints as Sishenchong (EX-HN 1 ), Baihui (GV 20), bilateral Fengchi (GB 20), Benshen (GB 13) and Neiguan (PC 6) were punctured with filiform needies and stimulated electrically by setting the stimulating parameters being dense-sparse waves, frequency of 14-26 pulses/min, strength of 3 - 5 mA and duration of 30 min. The treatment was conducted once daily, 5 times a week and continuously for 6 weeks. Patients of medication group were ordered to take Nimotop (30 mg/time), 3 times everyday and continuously for 6 weeks. Modified Hastgawa Dementia Scale (HDS) and Wilson's Memory Scale (WMS) were used to evaluate the patients' cognitive function, memory ability and general conditions before and after the treatment. Results: After the treatment, according to HDS, of the 20 and 25 cases in medication and EA groups, 1 (5%) and 4 (16%) experienced marked improvement, 5 (25%) and 15 (60%) had moderate improvement, 10 (50%)and 5 (20%) had mild improvement, and4 (20%) and 1 (4%) hadno improvement, with the total effective rates being 80% and 96% respectively. Rank test showed that the therapeutic effect of EA group was significantly superior to that of medication group ( P〈 0.05) in improving patients' cognitive function. Serf-comparison indicated that WMS of both groups increased significantly after the treatment ( P 〈 0.001, 0.05), including adding test of longterm memory and touching test of short-term memory in medication group, counting-down test of long-term memory, association test and touching test of short-term memory in EA group; and the effects of EA were apparently superior to those of medication in raising WMS (MQ), counting-down test and association test ( P 〈 0.05, 0.01 ). Conclusion: The therapeutic effect of EA is significantly superior to that of Nimotop in improving DM patients' cognitive function, learning and menory ability.
出处
《针刺研究》
CAS
CSCD
2006年第4期232-234,238,共4页
Acupuncture Research
关键词
糖尿病性认知功能障碍
学习记忆能力
电针
尼莫通
Diabetic cognitive dysfunction Learning and memory ability Electroacupuncture Nimotop