电针对糖尿病性认知功能障碍患者学习记忆的影响

Influence of Electroacupuncture on Learning and Memory Ability in Diabetic Cognitive Dysfunction Patients

目的：观察电针对糖尿病性认知功能障碍患者学习记忆的改善作用，并与尼莫通作对照。方法：将45例符合诊断标准的患者随机分为电针组25例，对照组20例。电针组取四神聪、百会、风池、本神、内关为主穴，电针为疏密波，频率14～26次／min，强度3～5mA，每次治疗30min，每日1次，连续5d后休息2d，共6周。对照组口服尼莫通，每次30mg，每日3次，连续治疗6周。对两组治疗前后进行长谷111痴呆修改量表评分及韦氏记忆量表（wMs）评定。结果：两组疗效的差异具有显著性意义，电针组疗效优于对照组；治疗前两组WMS（总记忆商）无显著差异，P〉0．05，治疗后电针组WMS评分明显上升，P〈0．05，而对照组虽然也有上升，但不显著，P〉0．05。电针组治疗后WMS在顺数、联想、触摸方面有显著上升，P〈0．05；而对照组WMS在累加、触摸方面有显著上升，P〈0．05；其余各项两组均表现为治疗前后差异不显著，P〉0．05。结论：电针能改善糖尿病性认知功能障碍患者的认知功能和学习记忆能力。

Objective： To observe the effect of electroacupuncture （EA） on the learning and rnenory ability in diabetic cognitive dysfunction patients. Methods： Forty-five cases of diabetic mellitus （DM） patients with cognitive dysfunction were randomly divided into EA group （n=25） and medication group （n=20）, For patients of EA group, main acupoints as Sishenchong （EX-HN 1 ）, Baihui （GV 20）, bilateral Fengchi （GB 20）, Benshen （GB 13） and Neiguan （PC 6） were punctured with filiform needies and stimulated electrically by setting the stimulating parameters being dense-sparse waves, frequency of 14-26 pulses/min, strength of 3 - 5 mA and duration of 30 min. The treatment was conducted once daily, 5 times a week and continuously for 6 weeks. Patients of medication group were ordered to take Nimotop （30 mg/time）, 3 times everyday and continuously for 6 weeks. Modified Hastgawa Dementia Scale （HDS） and Wilson＇s Memory Scale （WMS） were used to evaluate the patients＇ cognitive function, memory ability and general conditions before and after the treatment. Results： After the treatment, according to HDS, of the 20 and 25 cases in medication and EA groups, 1 （5%） and 4 （16%） experienced marked improvement, 5 （25%） and 15 （60%） had moderate improvement, 10 （50%）and 5 （20%） had mild improvement, and4 （20%） and 1 （4%） hadno improvement, with the total effective rates being 80% and 96% respectively. Rank test showed that the therapeutic effect of EA group was significantly superior to that of medication group （ P〈 0.05） in improving patients＇ cognitive function. Serf-comparison indicated that WMS of both groups increased significantly after the treatment （ P 〈 0.001, 0.05）, including adding test of longterm memory and touching test of short-term memory in medication group, counting-down test of long-term memory, association test and touching test of short-term memory in EA group; and the effects of EA were apparently superior to those of medication in raising WMS （MQ）, counting-down test and association test （ P 〈 0.05, 0.01 ）. Conclusion： The therapeutic effect of EA is significantly superior to that of Nimotop in improving DM patients＇ cognitive function, learning and menory ability.