正交法优选薄荷脑红外光谱鉴别中压片条件

The Condition of Optimun Seeking Menthol Infrared Spectrum to Identification the Preparing Disk with Orthogonal Design

目的探索一种确定薄荷脑红外光谱鉴别中压片最佳条件的科学方法,以获得最理想的红外光谱图。方法以三因素的3个水平,即薄荷脑:溴化钾(m g∶m g)分别为0.8∶100、2.3∶100、1.6∶100,压片压力分别为18mPa、24mPa、30mPa,压片时间分别为2m in、3m in、4m in,按正交设计实验,以输出的红外光谱图的基线值和最强吸收峰的透光率T%为指标,确定影响红外光谱图的主次因素,从而确定压片最佳条件。结果以薄荷脑与溴化钾比例为1.6∶100,压力为24mPa,压片时间为2m in为最佳条件,红外光图谱质量最好,基线在98%透光率以上,最强吸收峰在透光率4%以下。结论正交法优选薄荷脑红外光谱鉴别中压片条件,能以较少次数操作获得满意结果。

OBJECTIVE To expolre a scientism of the best condition to define the Menthol infrared spectrum to identification preparing disc in order to get satisfied infrared spectrum. METHODS Using three level of three factors, that is Menthol is to potassium Bromine（mg ＂ mg） as 0.8 is to 100,2.3 is to 100, 1.6 is to 100 separately. Discing pressure is 18mPa, 24mPa and 30mPa sparately. Discing time is 2min, 3min and 4min separately. According to the experiment with orthogonal design, using the output of baseline value and the strongest absorbance peak of transmittance T% as target to define the main factor strongest absorbance peak of transmittance T% as target to define the main factor which influence infrared spectra to define the best condition of preparing disc. RESULTS When the proportion of Menthol and potassium Bromine is 1.6 is to 100,pressure is 24mPa and time is 2min,the codition and the quality of the infrared spectrum is the best,the transmittance of baseline is more than 98%,and the transmittance of the strongest absorbance peak is under4%. CONCLUSION The condition of optimun seeking Menthol infrared spectrum to identification the preparing disk with orthogonal design can get the satisfied result with few transactions and it provide the scientism method.