168例胆石病危险因素病例对照研究

A Case-control Study on Risk Factors of 168 Cases of Cholelithiasis

目的探讨宁夏地区回汉民族胆石病危险因素,为临床决策及人群预防提供参考依据。方法按性别、年龄、民族1:1配对原则,选择宁夏地区168名胆石病病例和对照进行回顾性流行病学因素调查,采用单因素和多因素条件Logoistic回归分析。结果胆囊炎(OR=35.273)、油腻饮食(OR=7.063)、家族史(OR=3.476)、体质指数(OR=2.314)、甘油三酯(OR=2.459)、孕次(OR=2.033)、糖尿病史(OR=1.799)等因素与胆石病的发生呈正关联,而坚持吃早餐(OR=0.528)、使用解痉利胆药物(OR=0.509)等因素与胆石病的发生呈负关联。结论胆囊炎、家族史、油腻饮食、体质指数、甘油三酯、多孕次、糖尿病是宁夏地区胆石病的危险因素,而坚持吃早餐和使用解痉利胆药物是胆石病的保护因素。

Objective To explore the risk factors of cholelithiasis in mixed residential of Hui and Hart nationalities in Ningxia area. Methods A 1 ： 1 case-control study was conducted on 168 cases and 168 controls matched with sex, age and nationality. The odds ratios（ OR ） linking cholelithia factors were estimated by conditional multiple logistic regression analysis. Results Cholecystitis（ OR = 35.273）, oily food （ OR =7.063）, family history of cholelithiasis（ OR = 3.476）, body mass index （ OR =2.314）, serum triglycerides（ OR =2.459） , number of pregnancies（ OR = 2.033）, history of diabetes meUitus （ OR = 1.799）were significantly positively correlated with cholelithiasis, while having breakfast （ OR = 0.528） and biliary antispasmodic （ OR =0.509） were significantly negatively correlated with cholelithi correlated with cholelithiasis. Conclusion Cholecystitis, oily food, family history of cholelithiasis, body mass index, serum triglycefides, number of pregnancies, history of diabetes meUitus were major risk factors of cholelithiasis, while having breakfast and biliary antispasmodic were significantly protective factors of cholelithiasis in Ningxia.