慢性乙型肝炎肝穿病理与血清HBV DNA及肝功能的关系

Evaluation of Correlation Between Hepatic Pathohistology of Biopsies and Liver Function or Serum HBV DNA in Patients with Chronic Hepatitis B

目的评价慢性乙型肝炎病人肝穿病理分期、分级与乙肝病毒(HBV)病毒载量及肝功能的关系。方法对82例慢性乙型肝炎患者的血清病毒载量、肝功能及肝穿病理分级、分期进行对比分析。结果血清总胆汁酸(TBA)有助于判断慢性乙型肝炎肝脏的炎症及纤维化程度(P<0.01),丙氨酸转氨酶(ALT)对肝脏炎症程度的评估有意义(P<0.05),HBV病毒载量和肝细胞炎症相关(P<0.05)。结论TBA、ALT是评价肝脏炎症的有用指标;TBA对判断肝纤维化程度有价值。病毒载量可作为判断肝脏炎症程度的参考指标。

Objective To evaluate correlation between hepatic damage or hepatic fibrosis and liver function including total bile acid, alanine aminotransferase or quantity of serum HBV DNA in patients with chronic hepatitis B. Methods eighty-two biopsies in patients with chronic hepatitis B were reviewed pathohistologically. Serum samples for liver function test and quantity of HBVDNA were collected simultaneously half a month before and after the biopsy. The correlations between the results were assessed. Results The inflammatory staging and fibrotic scoring grading were significantly correlated with total bile acid, and inflammatory staging correlated with alanine aminotransferase or quantity of serum HBV DNA. Conclusion Serum total bile acid is considered to be the valuable reference for clinical diagnosis for hepatic inflammatory and fibrosis staging and alanine aminotransferase and the quantity of serum HBVDNA to be valuable for hepatic inflammation.