围术期应用恩丹西酮预防术后恶心和呕吐的临床研究

Clinic Study on Preventing Postoperative Nausea and Vomiting with Ondansetron During the Peroperative Period

目的观察比较围术期应用恩丹西酮减少患者术后恶心、呕吐的程度。方法随机选择腹部和胸部手术患者各90例。分为3组:1)恩丹西酮Ⅰ组,术中静脉滴注恩丹西酮4 mg(溶于生理盐水20 mL);2)恩丹西酮Ⅱ组,术中静脉滴注恩丹西酮4 mg(溶于生理盐水20 mL),8 h后重复静脉滴注恩丹西酮4 mg(溶于生理盐水20 mL);3)对照组,术中静滴生理盐水20 mL。结果恩丹西酮Ⅰ组、Ⅱ组术后恶心、呕吐发生率及程度均较对照组明显降低(P<0.05)。结论恩丹西酮对预防全麻患者术后恶心、呕吐的发生有显著效果。

Objective Application of ondansetron is aimed at reducing the postoperative nausea and vomiting. Methods 180 patients who underwent abdomen or chest operation （90-each） were randomly divided into 3 groups. Ondansetron group Ⅰ ： The patients received a bolus of ondansetron 4 mg （in normal saline 20 mL） intravenously during operations. Ondansetron group Ⅱ The patients received a bolus of ondansetron 4 mg （in normal saline 20 mL） intravenously during operations, and repeatedly received ondansetron 4 mg （in normal saline 20 mL） 8 h there after. Control group.. The patients received a bolus of normal saline 20 mL during operations. Results Observing the postoperative nausea and vomiting, it showed that the incidence and intensity of nausea for both group Ⅰ and Ⅱ after abdomen and chest operations were much lower than the control group（P〈0.05）. Conclusion Ondansetron has a significant effect on preventing the occurrence of postoperative nausea and vomiting.