凋亡相关基因在眼眶腺样囊性癌组织中的表达意义

Expression of of P53 and Bcl-2 in orbital adenoid cystic carcinoma

目的:分析凋亡相关基因p53和bcl-2在眼眶腺样囊性癌组织中的表达,分析其关系及临床意义。方法:免疫组化法检测51例眼眶腺样囊性癌临床标本和10例正常眼眶组织中P53和Bcl-2蛋白的表达状况。结果:P53和Bcl-2在眼眶腺样囊性癌组织中的表达阳性率分别为53%和65%,显著高于眼眶正常组织(53%,65%vs10%,P<0.01)。实性型腺样囊性癌中P53的表达率显著高于其在腺样-管状型中的表达率(86%vs30%,P<0.01);P53和Bcl-2在复发组中的表达率显著高于其在初发组中的表达率(85%vs42%,P<0.01),(100%vs53%,P<0.01);P53和Bcl-2二者在表达上具有相关性(χ2=1.461,P>0.05)。结论:P53和Bcl-2蛋白的检测对于判断肿瘤对化疗的敏感性和预后有参考价值。

AIM： To study the expression and clinical significances of P53 and Bcl-2 in orbital adenoid cystic carcinoma, and to provide theoretical information and clinical references for evaluating the prognosis of orbital adenoid cystic carcinoma. METHODS： The expression of P53 and Bcl-2 in 51 cases of orbital adenoid cystic carcinoma and 10 cases of normal orbital tissues were detected by immunohistochemisry analysis. RESULTS： P53 and Bcl-2 expression percentage were 53% and 65% respectively in orbital adenoid cystic carcinoma and were higher than in normal orbital tissues （vs 10%, P〈 0.01 ）. The positive rate of P53 expression in adenoid-tubular ACC was higher than in solid ACC （86% vs 30%,P〈0.01）. The positive rate of P53 and Bcl-2 expression in recurrent tumor group was higher than in primary tumor group （85% vs 42%, P〈0.01） （100% vs 53%, P〈0.01）. Significant correlation was found between the expression of P53 and Bcl-2 （X^ 2=1.461, P 〉0.05）. CONCLUSION： The overexpressions of P53 and Bcl-2 were participated in the acquired drug resistance in orbital adenoid cystic carcinoma, and the detection were of great value in the prognosis evaluation.