中老年男性高尿酸血症患者血浆PAI-1和内皮素水平升高

Elevation of plasminogen activator inhibitor-1 and endothelin levels in middle aged and old male patients with hyperuricemia

测定单纯高尿酸血症及其合并糖脂代谢紊乱患者血浆纤溶酶原激活物抑制物1(PAI-1)和内皮素水平。结果显示高尿酸血症患者血浆PAI-1、内皮素水平明显高于正常对照者(均P<0．01),提示高尿酸血症与血管内皮细胞损伤有关。

Serum plasminogen activator inhibitor-1 （ PAI-1 ） and endothelin （ET） levels were measured in patients with simple hyperuricemia or combined with hyperlipidaemia and hyperglycemia. The results showed that PAI-1 and ET levels in patients with hyperuricemia were notably higher than those in the control group（ both P 〈 0.01 ） , suggesting that there is a correlation between hyperuricemia and impaired vascular endothelium.