摘要
分别以高葡萄糖、高胰岛素、过氧化氢和糖基化终产物孵育大鼠肾小球系膜细胞(RGMC),均可使RGMC环氧化酶(COX)-2 mRNA和蛋白表达增加(均P<0．01);亚硒酸钠预处理后可抑制上述4种因素诱导的COX-2 mRNA和蛋白表达。亚硒酸钠可能通过抑制COX-2在RGMC的表达,从而在防治糖尿病肾病发生发展过程中发挥重要作用。
The expression of cyclooxygenase-2 （ COX-2 ） mRNA and protein was significantly increased in rat glomerular mesangial ceils （RGMC） treated separately with high glucose, high insulin, H2O2 and advanced glycosylation end products, The expressions of COX-2 mRNA and protein in RGMC induced by above 4 factors were distinctly inhibited by sodium selenite, suggesting that sodium selenite might play a significant role in the prevention of diabetic nephropathy via this mechanism.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2006年第4期376-377,共2页
Chinese Journal of Endocrinology and Metabolism
