胰岛β细胞量与糖尿病临床进程

Islet β-cell mass and clinical progression of diabetes mellitus

正常情况下胰岛β细胞量受到β细胞复制、新生、凋亡和细胞体积变化等机制调节。2型糖尿病患者的β细胞量较非糖尿病者明显减少,造成细胞量减少的原因主要是凋亡增多。胰岛β细胞量的变化对糖尿病的临床进程起重要作用。

Normally, pancreatic islet β-cell mass is regulated by β-cell replication, neogenesis, apoptosis and cell size. β-cell mass in diabetic patients is conspicuously less than that in normal persons. Decline of β-cell mass is mainly caused by increased β-cell apoptosis. The change of β-cell mass is clinically becoming more and more important in regard to the progression of diabetes mellitus.