恶性肿瘤患者血清纤维蛋白原的临床意义

Clinical significance of plasma fibrinogen in patients with malignant tumor

目的:探讨血浆纤维蛋白原(fibrinogen;Fbg)水平与恶性肿瘤的关系,并研究其在肿瘤化疗过程中的变化情况。方法:采用Sysmex CA-7000全自动血栓止血测定仪测定48例恶性肿瘤患者的血浆Fbg水平及其化疗后的Fbg水平,并以40例健康体检者为对照组。结果:恶性肿瘤患者血浆Fbg明显高于对照组(P<0.01),但不同类型肿瘤患者Fbg含量无统计学差异(P>0.05)。治疗后缓解的患者血浆Fbg含量较前明显降低(P<0.01),未缓解者治疗前后Fbg水平无统计学差异(P>0.05)。结论:血浆Fbg水平在恶性肿瘤的辅助诊断及疗效判断方面有一定临床意义。

Objective：To study the significance of plasma fibrinogen （Fbg） in patients with malignant tumor . Methods： Sysmex CA -7000 automated coagulation analyzer was used to detect Fbg in 48 patients with malignant tumor before and after treatment. Results： Fbg level increased obviously in patients with malignant tumor than that in control group（P 〈 0.01 ） ,but there was no significant difference in different types of malignant tumor（P 〉 0.05） ,Fbg level decreased significantly in patients with curative effect（ P 〈 0.01 ）. otherwise it didn＇t change in patients without effet（ P 〉 0.05）. Conclusion ： Fbg level plays an important roles in the diagnosis and evaluation of therapy in patients with malignant tumor.