维甲酸、化疗、低剂量肝素防治急性早幼粒细胞性白血病并DIC20例

Effectiveness of all-trans tretinoin acid chemotherapy with low dosage heparin in treatment of acute promyelocytic leukemia with disseminated intravascular coagulation

目的:总结维甲酸、化疗、低剂量肝素合用治疗急性早幼粒细胞性白血病(APL)并弥漫性血管内凝血(DIC)的疗效。方法:20例并发DIC的APL患者,采用全反式维甲酸(ATRA)、适量化疗诱导分化至完全缓解(CR),同时予以小剂量肝素。结果:APL的完全缓解率达86%,平均缓解时间达37.4天。DIC的有效率达76.5%。结论:维甲酸、化疗、低分子肝素合用治疗急性早幼粒细胞性白血病并DIC疗效明显,值得临床推广使用。

Objective：To obsereve the effectiveness of all -trans tretinoin acid chemotherapy in combination with low dosage heparin in treatment of acute promye locytic leukemia（APL） with disseminated intravascular coagulation （DIC）. Methods ：Twenty patients with APL and DIC, were treated by all - trans tretinoin acid chemotherapy and low dosage heparin. Rusults：Among twenty patients, the complete remission （CR）rate was 86%, average remission time was 37.4 days,the efficiency rate of DIC was 76.5%. Condusion： All - trans tretinoin acid chemotherapy in combination with low dosage heparin in the treatment of APL with DIC can obtain obvious effect.