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心肌缺血/再灌注损伤的内源性保护机制研究进展 被引量：29

Advances in study of endogenous protective mechanisms of cardiac ischemia/reperfusion injuries
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摘要 缺血预适应是目前治疗缺血/再灌注损伤最为有效方法之一,其机制是通过调动机体内源性保护体系而发挥作用。但由于缺血预适应在临床难以实施,随之出现了药物预适应,它可分为受体和非受体依赖2种,是心肌缺血/再灌注损伤治疗研究热点。 Currently ischemic preconditioning is one of the most efficacious ways to treat ischemia reperfusion via triggering endogenously protective system. However, pharmacologic preconditioning has been produced due to the difficulty of performing ischemia precondiioning. Pharmacologic preconditioning, including both receptors and non-receptors, is actively investigated for the treatment of ischemia reperfusion.
作者 曹泽玲 杨庭树 龙超良 汪海
机构地区 军事医学科学院毒物药物研究所 解放军总医院心内科
出处 《中国药理学通报》 CAS CSCD 北大核心 2006年第8期912-916,共5页 Chinese Pharmacological Bulletin
关键词 缺血/再灌注损伤 缺血预适应 药物预处理 ischemia reperfusion injury ischemic preconditioning pharmacologic preconditioning
分类号 R-05 [医药卫生] R322.11 [医药卫生—人体解剖和组织胚胎学]
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参考文献24

  • 1Liem D A,Gho C C,Gho B C,et al.The tyrosine phosphatase inhibitor bis (maltolato) oxovanadium attenuates myocardial reperfusion injury by opening ATP-sensitive potassium channels[J].J Pharmacol Exp Ther,2004,309 (3):1256-62.
  • 2Obata T.Adenosine production and its interaction with protection of ischemic and reperfusion injury of the myocardium[J].Life Sci,2002,71(18):2083-103.
  • 3Vanden-Hoek T,Becker L B,Shao Z H,et al.Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion[J].Circ Rex,2000,86(5):541-8.
  • 4Zhao Z Q,Johansen J V.Myocardial apoptosis and ischemic preconditioning[J].J Cardiovasc Res,2002,55(3):438-55.
  • 5Tsai C H,Su S F,Chou T F.Differential effects of sarcolemmal and mitochondrial K (ATP) channels activated by 17 beta-estradiol on reperfusion arrhythmias and infarct sizes in canine hearts[J].J Pharmacol Exp Ther,2002,301(1):234-40.
  • 6Grover G J,Garlid K D.ATP-Senditive potassium channels:a review of their cardioprotective pharmacology[J].J Mol Cell Cardiol,2000,32(4):677 -95.
  • 7Juan A,Grstanello J A,Doliba N M,et al.Opening of potassium channels protects mitochondrial function from calciym over load[J].J Surg Res,2000,94(2):116-23.
  • 8Kowaltowski A J,Seetharaman S,Paucck P.Bioenergetic consequences of opening the ATP-sensitive K+ channel of heart mitochondria[J].Am J Physiol Heart Cir Physiol,2001,280(2):649-57.
  • 9Ozcan C,Bienengraeber M,Dzeja P P,et al.Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation[J].Am J Physiol Heart Circ Physiol,2002,282(2):H531-9.
  • 10Akao M,Ohler A,O'Rourke B,Marban E.Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells[J].Circ Res,2001,88:1267-75.

二级参考文献6

  • 1Chen LD, Tan DX, Reiter RJ et al. In vivo and in vitro effects of the pineal and melatonin on [Ca^2+ -Mg^2+] dependent ATPase in cardiac sarcolemma[J].J Pineal Res,1993,14:178-83.
  • 2Tan DX, Chen LD, Poegeler LC et al. Melatonin: A potent endogenous hydroxyl radical scavenger[J].Endocrine J,1993,1(1):57-60.
  • 3Morishima I, Matsui H, Mukawa H et al. Melatonin, a pineal hormone with antioxidant property,protects against adriamycin cardiomyopathy in rats[J]. Life Sci,1998,63(7):511-21.
  • 4Tang PL, Xu MF, Qian ZM.Differential behaviour of cell membranes towards iron-induced oxidative damage and the effects of melatonin[J].Biol Signals,1997,6(4-6):291-300.
  • 5Cuzzocrea S, Tan DX, Costantino G et al.The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat[J].FASEB J,1999,13(14):1930-8.
  • 6李明阳,田侠,侯京武,赵保路,忻文娟.褪黑素拮抗鼠肝线粒体自由基产生的实验研究[J].中国药理学通报,1998,14(3):260-262. 被引量：7

共引文献6

同被引文献346

引证文献29

二级引证文献181

中国药理学通报
2006年 第8期

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