A型流感病毒非结构蛋白的功能及临床应用

The Function and Clinical Application of The Non-structural Protein of The Type A Influenza Virus

NS1蛋白作为A型流感病毒的非结构蛋白,最初的研究着重于它对宿主细胞蛋白质合成的抑制作用方面考虑.随着研究的深入,对其基因的进化、蛋白质的抗原性作了详细的研究,同时发现流感病毒的NS1蛋白与流感病毒所诱导的细胞凋亡之间存在一定的联系,其对凋亡的调节作用与流感病毒感染的细胞是否产生干扰素及其所感染的细胞系直接相关.NS1蛋白能够抑制病毒感染细胞干扰素的产生,在流感病毒拮抗干扰素的抗病毒效应中发挥了重要的作用,许多研究表明,这种干扰素拮抗作用可能与流感病毒的毒力有关.由于传统疫苗的广泛应用,NS1蛋白在临床应用中作为鉴别诊断免疫禽和自然感染禽的检测抗原具有广阔的前景.

The first research on the NS1 protein as the non-structural protein of the type A influenza virus was emphasized on the considering of its depressant effect on the composition of the protein of host cell. And now, with deep research, the evolution of its genes and the antigenicity of its protein have been explained. The NS1 protein of influenza virus has the association with the apoptosis induced by the influenza virus, the regulating function of apoptosis has the direct correlation with possibility of producing interference and the cell line infected by influenza virus. The NS1 protein restrained to producing the interferon by infected cell. The NS1 protein plays an important role on the host anti-viral cytokine responses, it possesses nagitive regulation for interferon＇s antiviral activity, most observation indicated nagitive regulation might associate with the virulence of influenza virus. Furthermore NS1 protein as an inspection antigen to differentiate and diagnose the poultry which was immunized or naturally infected has a very wide prospect, because the traditional vaccine was used extensively.