期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

G蛋白偶联受体二聚化研究进展 被引量：6

Dimerization of G protein-coupled receptors and its possible role in signaling trasduction
下载PDF
导出
摘要 G蛋白偶联受体(GPCR s)是最大的细胞膜受体家族,具有七螺旋跨膜肽段结构。近年来,越来越多的研究认为这些受体以二聚体的形式参与调节生理活动,对信号识别及转导有重要作用。随着生物技术及分子生物学的发展,GPCRs二聚体研究已取得了很大的进展。该文就这些方面及同源、异源二聚体对受体结合及信号转导的重要作用作一简述。 G-protein coupled receptors （GPCRs） belong to the biggest subfamily of transmembran receptors. Recently, more and more research has been suggested that the dimerization of GPCRs may regulate the physiological and pharmacological activity. With the development of biochemistry technology and molecular biology, a great progress has been achieved in the field of the dimerization of GPCRs. This article will generally demonstrate that the vital roles of the homodimerization and heterdimerization.
作者 张从芬 彭代银 李庆林 池志强 刘景根
机构地区 安徽中医学院药学院 中国科学院上海药物研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2006年第7期774-779,共6页 Chinese Pharmacological Bulletin
基金 国家重点基础研究发展规划(973计划)资助项目(No2003CB515400) 中科院"百人计划"研究基金 国家杰出青年科学基金资助项目(No30425002)
关键词 G蛋白偶联受体 二聚化 受体结合 信号转导 GPCRs dimerization receptor binding signal transduction
分类号 R-05 [医药卫生] R341.3 [医药卫生—基础医学]
  • 相关文献

参考文献25

  • 1Angers S, Salahpour A, Bouvier M. Dimefization: An emerging concept for G protein-coupled receptor ontogeny and function [J].Ann Rev Pharma Toxic ,2002,42:409 - 35.
  • 2Gouldson P R, Dean M K, Snell C R, et al. Lipid-facing correlated mutations and dimerization in G-protein coupled receptors [J].Protein Eng, 2001,14:759 - 67.
  • 3Joe Bockaert, Jean Philippe Pin. Molecular tinkering of G protein - coupled receptors : an evolutionary success [J]. EMBO, 1999,18 : 1723 - 9.
  • 4Comes I, Jordan B A, Gupta A,et al. G protein coupled receptor dimerization : implications in modulating receptor function [J]. J Mol Med,2001,79(5 -6) : 226 -42.
  • 5Gether U. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors [J]. Endocrine Rev, 2000,21 : 90 -113.
  • 6Brown E M, Segre G V, Goldfing S R. Serpentine receptors for parathyroid hormone, calcitonin and extra cellular calcium ions [J].Baillieres Clin Endocrinol Metab, 1996,10 : 123 - 61.
  • 7Wess J. Molecular basis of receptor/G-protein-coupling selectivity[J]. Pharmacol Ther, 1998,80:231 - 64.
  • 8Hebert T E, Moffett S, Morello J P,et al. A peptide derived from a β2-adrenergic receptor transmembrane domain inhibits both receptor dimefization and activation [J]. J Biol Chem, 1996,271 :16384 -92.
  • 9Angers S, Salahpour A, Joly E, et al. Detection of beta 2-adrenergic receptor dimefization in living cells using bioluminescence resonance energy transfer(BRET) [J]. Proc Natl Acad Sci USA,2000.97:3684 - 9.
  • 10Rocheville M, Lange D C, Kumar U, et al. Subtypes of the soma-tostatin receptor assemble as functional homo and heterodimers[J]. J Biol Chem,2000 ,275 :7862 -786.

二级参考文献27

  • 1Seifert R, Wenzel-Seifert K. Constitutive activity of G-protein-coupled receptors: Cause of disease and common property of wild-type receptors[J]. Naunyn-Schmiedebergs Arch Pharmacol,2002,366: 381-416.
  • 2Chen G, Way J, Armour S et al. Use of Constitutive G protein-coupled receptor activity for drug discovery. Mol Pharmacol,2000,57: 125-34.
  • 3Ren Q, Kurose H, Lefkowitz RJ, Cotecchia S. Constitutively active mutants of the 2-adrenergic receptor[J]. J Biol Chem,1993, 268:16483-7.
  • 4Zaki PA, Keith DEJr, Thomas JB et al. Agonist-,Antagonist-,and inverse agonist-regulated trafficking of the-opioid receptor correlates with,but does not require, G protein activation[J]. J Pharmacol Exp Ther,2001,298(3): 1015-20.
  • 5Seifert R, Wenzel-Seifert K. The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors[J]. Life Sci,2003,73(18):2263-80.
  • 6Cussac D, Pasteau V, Mark J. Millan Characterisation of Gs activation by dopamine D1 receptors using an antibody capture assay: antagonist properties of clozapine[J]. Eur J Pharmacol,2004,485:111-7.
  • 7Richard F, Barroso S, Martinez J et al. Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2[J]. Mol Pharmacol, 2001,60(6):1392-8.
  • 8Egan CT, Herrick-Davis K, Teithlr M. Creation of a constitutively activated state of the 5-hydroxytryptamine2A receptor by site-directed mutagenesis: inverse agonist activity of antipsychotic drugs. J Pharmacol Exp, 1998,286(1):85-90.
  • 9Jinsi-Parimoo A,Gershengom MC. Constitutive activity of native thyrotropin-releasing hormone receptors revealed using a protein kinase C-responsive reporter gene. Endocrinology J,1997,138(4):1471-5.
  • 10Wilbanks AM, Laporte SA, Bohn LM et al. Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. Biochemistry,2002,41(40):11981-9.

共引文献5

同被引文献145

引证文献6

二级引证文献7

中国药理学通报
2006年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部