中性粒细胞弹性蛋白酶——神经保护的作用新靶点

Neutrophil elastase: a target of neuroprotection

许多种组织、器官损伤(尤其缺血/再灌注损伤)后,中性粒细胞浸润,释放大量的弹性蛋白酶加重这些组织的损伤。脑缺血、脑出血、脑外伤等导致的脑损伤都伴有中性粒细胞向脑组织的浸润。因此,中性粒细胞所释放的弹性蛋白酶在脑损伤中可能也具有重要作用。该文对中性粒细胞弹性蛋白酶在脑损伤中的作用及作用机制进行了综述。

Tissue or organic injuries（ especially induced by ischemia/reperfusion） are often followed by inflammatory response characterized with neutrophil infiltration. Neutrophils exacerbate tissue or organic injuries by releasing elastase. Since brain injuries induced by cerebral ischemia/reperfusion, intracerebral hemor-rhage, cerebral trauma also accompany infiltration of neutrophil, and elastase derived from neutrophil probably plays an important role in brain injury.